Florida State University

Dr. Mohamed Kabbaj

Professor of Biomedical Sciences & Neuroscience

Biomedical Sciences
MSR 3300H


The focus of our research is to understand the neurobiology underlying individual differences and sex differences in depression and drug addiction. Another focus of our research is to examine epigenetic mechanisms underlying social behaviors.
Recent Publications
Saland SK, Duclot F, Kabbaj M, Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes, Curr Opin Behav Sci, 2017 PubMed
Dossat AM, Sanchez-Gonzalez MA, Koutnik AP, Leitner S, Ruiz EL, Griffin B, Rosenberg JT, Grant SC, Fincham FD, Pinto JR, Kabbaj M, Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy, FASEB J, 2017 PubMed
Duclot F, Kabbaj M, Comparative transcriptomic analysis of the effects of antidepressant drugs in stress-susceptible mice, Biol Psychiatry , 2017 PubMed
Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Wright KN, Mouzon E, Kabbaj M, Neve R, Turecki G, Shen L, Nestler EJ, Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine, Neuroscience, 2017 PubMed
Strong CE, Schoepfer KJ, Dossat AM, Saland SK, Wright KN, Kabbaj M, Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats, Neuropharmacology, 2017 PubMed
Dossat AM, Jourdi H, Wright KN, Strong CE, Sarkar A, Kabbaj M, Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats, Neuroscience, 2017 PubMed
Wright KN, Strong CE, Addonizio MN, Brownstein NC, Kabbaj M, Reinforcing properties of an intermittent, low does of ketamine in rats: effects of sex and cycle, Psychopharmacology (Berl), 2017 PubMed
Duclot F, Perez-Taboada I, Wright KN, Kabbaj M, Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine, Neuropharmacology, 2016 PubMed
Duclot F, Wang H, Youssef C, Liu Y, Wang Z, Kabbaj M, Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster), Horm Behav, 2016 PubMed
Saland SK, Schoepfer KJ, Kabbaj M, Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner, Sci Rep, 2016 PubMed
Sarkar A, Kabbaj M, Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats, Biol Psychiatry, 2016 PubMed
Duclot F, Kabbaj M, Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants, J Exp Biol, 2015 PubMed
Sanchez-Gonzalez MA, Guzik P, May RW, Koutnik AP, Hughes R, Muniz S, Kabbaj M, Fincham FD, Trait anxiety mimics age-related cardiovascular autonomic modulation in young adults, J Hum Hypertens, 2015 PubMed
Wright KN, Hollis F, Duclot F, Dossat AM, Strong CE, Francis TC, Mercer R, Feng J, Dietz DM, Lobo MK, Nestler EJ, Kabbaj M, Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner, J Neurosci, 2015 PubMed
Carrier N, Saland SK, Duclot F, He H, Mercer R, Kabbaj M, The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats, Biol Psychiatry, 2015 PubMed
Fang XQ, Qiao H, Groveman BR, Feng S, Pflueger M, Xin WK, Ali MK, Lin SX, Xu J, Duclot F, Kabbaj M, Wang W, Ding XS, Santiago-Sim T, Jiang XH, Salter MW, Yu XM, Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors, Mol Brain, 2015 PubMed
Duclot F, Kabbaj M, The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1, Genome Biol, 2015 PubMed
Ai AL, Kabbaj M, Kathy LL, Body affects mind? Preoperative behavioral and biological predictors for postoperative symptoms in mental health, J Behav Med, 2014 PubMed
Dweck D, Sanchez-Gonzalez MA, Chang AN, Dulce RA, Badger CD, Koutnik AP, Ruiz EL, Griffin B, Liang J, Kabbaj M, Fincham FD, Hare JM, Overton JM, Pinto JR, Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy, J Biol Chem, 2014 PubMed
McHenry JA, Carrier N, Hull EM, Kabbaj M, Sex differences in anxiety and depression: Role of testosterone, Front Neuroendocrinol, 2014 PubMed
Hollis F, Kabbaj M, Social defeat as an animal model for depression, ILAR J, 2014 PubMed
Hollis F, Isgor C, Kabbaj M, The consequences of adolescent chronic unpredictable stress exposure on brain and behavior, Neuroscience, 2013 PubMed
Sanchez-Gonzalez MA, May RW, Koutnik AP, Kabbaj M, Fincham FD, Sympathetic vasomotor tone is associated with depressive symptoms in young females: a potential link between depression and cardiovascular disease, Am J Hypertens, 2013 PubMed
Carrier N, Kabbaj M, Sex differences in the antidepressant effects of ketamine, Neuropharmacology, 2013 PubMed
Jourdi H, Kabbaj M, Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression, PLoS One, 2013 PubMed
Duclot F, Kabbaj M, Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression, J Neurosci, 2013 PubMed
Wang H, Duclot F, Liu Y, Wang Z, Kabbaj M, Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles, Nat Neurosci, 2013 PubMed
Carrier N, Kabbaj M, Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex, Neuroscience, 2012 PubMed
Hollis F, Gaval M, Carrier N, Dietz D, Kabbaj M, Juvenile And Adult Rats Differ In Cocaine Reward And Expression Of Zif268 In The Forebrain, Neuroscience, 2012 PubMed
Carrier N, Kabbaj M, Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats, Horm Behav, 2012 PubMed
Carrier N, Kabbaj M, Extracellular signal-regulated kinase 2 signaling in the hippocampus dentate gyrus mediates the antidepressant effects of testosterone, Biol Psychiatry, 2012 PubMed
Duclot F, Hollis F, Darcy MJ, Kabbaj M, Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders, Physiol Behav, 2011 PubMed
Hollis F, Duclot F, Gunjan A, Kabbaj M, Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus, Horm Behav, 2011 PubMed
Young KA, Liu Y, Gobrogge KL, Wang H, Kabbaj M, Wang Z, Amphetamine alters behavior and mesocorticolimbic dopamine receptor expression in the monogamous female prairie vole, Brain Res, 2011 PubMed
Calvo N, Cecchi M, Kabbaj M, Watson SJ, Akil H, Differential effects of social defeat in rats with high and low locomotor response to novelty, Neuroscience, 2011 PubMed
Radley JJ, Kabbaj M, Jacobson L, Heydendael W, Herman JP, Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes, Stress, 2011 PubMed
LaPlant Q et al., Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens, Nat Neurosci, 2010 PubMed
Liu Y, Aragona BJ, Young KA, Dietz DM, Kabbaj M, Mazei-Robison M, Nestler EJ, Wang ZX, Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species, Proc Natl Acad Sci U S A, 2010 PubMed
Stack A, Carrier N, Dietz D, Hollis F, Sorenson J, Kabbaj M, Sex differences in social interaction in rats: role of the immediate-early gene zif268, Neuropsychopharmacology, 2010 PubMed
Hollis F, Wang H, Dietz D, Gunjan A, Kabbaj M, The effects of repeated social defeat on long -term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague Dawley rats, Psychopharmacology (Berl), 2010 PubMed
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ, Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins, Neuron, 2009 PubMed
Dietz DM, Dietz KC, Moore S, Ouimet CC, Kabbaj M, Repeated social defeat stress-induced sensitization to the locomotor activating effects of d-amphetamine: role of individual differences, Psychopharmacology (Berl), 2008 PubMed
Kabbaj M, Isgor C, Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers, Neurosci Lett, 2007 PubMed
Kabbaj M, Morley-Fletcher S, Le Moal M, Maccari S, Individual differences in the effects of chronic prazosin hydrochloride treatment on hippocampal mineralocorticoid and glucocorticoid receptors, Eur J Neurosci, 2007 PubMed
Dietz D, Wang H, Kabbaj M, Corticosterone fails to produce conditioned place preference or conditioned place aversion in rats, Behav Brain Res, 2007 PubMed
Clinton SM, Vázquez DM, Kabbaj M, Kabbaj MH, Watson SJ, Akil H, Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behavior, Horm Behav, 2007 PubMed
Kabbaj M, Individual differences in vulnerability to drug abuse: the high responders/low responders model, CNS Neurol Disord Drug Targets, 2006 PubMed
Dietz DM, Tapocik J, Gaval-Cruz M, Kabbaj M, Dopamine transporter, but not tyrosine hydroxylase, may be implicated in determining individual differences in behavioral sensitization to amphetamine, Physiol Behav, 2005 PubMed
Kabbaj M, Evans S, Watson SJ, Akil H, The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences, Neuropharmacology, 2004 PubMed
Isgor C, Kabbaj M, Akil H, Watson SJ, Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats, Hippocampus, 2004 PubMed
Kabbaj M, Neurobiological bases of individual differences in emotional and stress responsiveness: high responders-low responders model, Arch Neurol, 2004 PubMed
Neal CR Jr, Weidemann G, Kabbaj M, Vázquez DM, Effect of neonatal dexamethasone exposure on growth and neurological development in the adult rat, Am J Physiol Regul Integr Comp Physiol, 2004 PubMed
Kabbaj M, Yoshida S, Numachi Y, Matsuoka H, Devine DP, Sato M, Methamphetamine differentially regulates hippocampal glucocorticoid and mineralocorticoid receptor mRNAs in Fischer and Lewis rats, Brain Res Mol Brain Res, 2003 PubMed
Isgor C, Cecchi M, Kabbaj M, Akil H, Watson SJ, Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone, Neuroscience, 2003 PubMed
Kabbaj M, Isgor C, Watson SJ, Akil H, Stress during adolescence alters behavioral sensitization to amphetamine, Neuroscience, 2002 PubMed
Evans SJ, Datson N, Kabbaj M, Thompson RC, Vreugdenhil, DeKloet ER, Watson SJ, Akil H, Evaluation of Affymetrix Gene Chip Sensitivity in rat hippocampal tissue using SAGE analysis, Eur J Neurosci, 2002 PubMed
Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ, Diurnal Rhythm of Agouti-Related Protein and Its Relation to Corticosterone and Food Intake, Endocrinology, 2002 PubMed
Kabbaj M, Akil H, Individual differences in novelty-seeking behavior in rats: a c-fos study, Neuroscience, 2001 PubMed
Kabbaj M, Norton CS, Kollack-Walker S, Watson SJ, Robinson TE, Akil H, Social Defeat alters the acquisition of cocaine self-administration in rats: role of Individual Differences in cocaine taking-behavior, Psychopharmacology (Berl), 2001 PubMed
Kabbaj M, Devine DP, Savage VR, Akil H, Neurobiological Correlates of Individual Differences in Novelty-Seeking Behavior in the Rat: Differential Expression of Stress-Related Molecules, J Neurosci, 2000 PubMed
Kabbaj M, Le Moal M, Maccari S, Hippocampal type I and type II corticosteroid receptors are differentially regulated by chronic prazosin treatment, Neuroscience, 1996 PubMed
Kabbaj M, Piazza PV, Simon H, Le Moal M, Maccari S, Opposite effects on hippocampal corticosteroid receptors induced by stimulation of beta and alpha-1 noradrenergic receptors, Neuroscience, 1995 PubMed
Maccari S, Piazza PV, Kabbaj M, Barbazanges A, Simon H, Le Moal M, Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress, J Neurosci, 1995 PubMed
Casolini P, Kabbaj M, Piazza PV, Angelucci L, Simon H, Le Moal M, Maccari S, The D1 dopamine agonist SKF 38393, but not the D2 agonist LY 171555, decreases the affinity of type II corticosteroid receptors in rat hippocampus and ventral striatum, Neuroscience, 1994 PubMed
Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S, Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats, J Neuroendocrinol, 1994 PubMed
Casolini P, Piazza PV, Kabbaj M, Leprat F, Angelucci L, Simon H, Le Moal M, Maccari S, The mesolimbic dopaminergic system exerts an inhibitory influence on brain corticosteroid receptor affinities, Neuroscience, 1993 PubMed
Casolini P, Kabbaj M, Leprat F, Piazza PV, Rougé-Pont F, Angelucci L, Simon H, Le Moal M, Maccari S, Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons, Brain Res, 1993 PubMed

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Alfonso Brea Guerrero, Graduate Student

Florian Duclot, Affiliate - Biomedical sciences

Devin Hagarty, Graduate Student

Jordan Logue, Graduate Student

Kristin Schoepfer, Graduate Student

Caroline Strong, Graduate Student

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