Justin Riddle

Our research identified a novel control signal that is engaged when participants are engaged in goal-directed behavior and decision-making. Low-frequency oscillations in prefrontal cortex coupled to high-frequency activity in the motor cortex during decision-making when the individual is incorporated their goals into the decision process. This prefrontal delta to motor beta cross-frequency coupling was also discovered to be reduced in patients with elevated symptoms of anhedonia in major depressive disorder. Multiple randomized clinical trials are underway to understand the neural mechanisms underlying this signal and to apply stimulation designed to restore delta-beta coupling in patients. Low-frequency network activity in the prefrontal cortex is also being investigated in the context of control over working memory. Working memory is the ability to maintain information in the absence of information in the environment. This process underlies higher-order cognition, is disrupted in psychiatric illness, and treatments for psychiatric illness target the prefrontal regions responsible for directing working memory. Our research is investigating how low-frequency oscillations organize activity in the frontal-parietal network to support control over working memory. Furthermore, we are developing brain stimulation tools to probe the causal role of these control signals and to understand how the prefrontal cortex contributes to working memory.Our research identified a novel control signal that is engaged when participants are engaged in goal-directed behavior and decision-making. Low-frequency oscillations in prefrontal cortex coupled to high-frequency activity in the motor cortex during decision-making when the individual is incorporated their goals into the decision process. This prefrontal delta to motor beta cross-frequency coupling was also discovered to be reduced in patients with elevated symptoms of anhedonia in major depressive disorder. Multiple randomized clinical trials are underway to understand the neural mechanisms underlying this signal and to apply stimulation designed to restore delta-beta coupling in patients. Low-frequency network activity in the prefrontal cortex is also being investigated in the context of control over working memory. Working memory is the ability to maintain information in the absence of information in the environment. This process underlies higher-order cognition, is disrupted in psychiatric illness, and treatments for psychiatric illness target the prefrontal regions responsible for directing working memory. Our research is investigating how low-frequency oscillations organize activity in the frontal-parietal network to support control over working memory. Furthermore, we are developing brain stimulation tools to probe the causal role of these control signals and to understand how the prefrontal cortex contributes to working memory.