Dr. Yi Zhou
Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 1350E
- Molecular and Neurobiological Basis of Mental Disorders; Functions and Regulation of Neuronal Ion Channels.
- Current Research
- A major focus of our research is to develop and characterize animal models for the study of human neuropsychiatric diseases. We have generated a line of transgenic mice that exhibit behavioral endophenotypes corresponding to the core symptoms of schizophrenia. Using a combination of electrophysiological, biochemical and imaging approaches, we also identified schizophrenia-related synaptic deficits in the brain of our mouse model. Currently, we are using this and other mouse models to investigate the neurobiology of schizophrenia at levels of molecules, synapses and neural circuits.
- Recent Publications
Wang Y, Wang YB, Sun H, Zhou A, Zhou Y & Li Y (2016). Sequential Posttranslational Modifications Regulate PKC Degradation. Molecular Biology of the Cell, 27(2):410-20. PubMed Yan Y, Bejoy J, Xia J, Guan J, Zhou Y, Li Y (2016). Neural patterning of human induced pluripotent stem cells in 3D cultures for studing biomolecule-directed differential cellular responses. Acta Biomater, 114-26. PubMed Foote M, Qiao H, Graham K, Wu Y, & Zhou Y (2015). Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biological Psychiatry, 78(6):386-95. PubMed Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y & Li Y (2015). 14-3-3tau promotes surface expression of Cav2.2 (alpha1B) Ca2+ channels. Journal of Biological Chemistry, 290(5):2689-98. PubMed