Yi Zhou
Interest
Molecular and Neurobiological Basis of Mental Disorders; Functions and Regulation of Neuronal Ion Channels.
Current Research
A major focus of our research is to develop and characterize animal models for the study of human neuropsychiatric diseases. We have generated a line of transgenic mice that exhibit behavioral endophenotypes corresponding to the core symptoms of schizophrenia. Using a combination of electrophysiological, biochemical and imaging approaches, we also identified schizophrenia-related synaptic deficits in the brain of our mouse model. Currently, we are using this and other mouse models to investigate the neurobiology of schizophrenia at levels of molecules, synapses and neural circuits.
Jones Z, Zhang J, Wu Y, & Zhou Y (2021). Inhibition of 14-3-3 proteins alters neural oscillations in mice. Frontiers in Neural Circuits. Front Neural Circuits , 15:647856. PubMed
Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG (2020). Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Mol Cell Biol , 21(1):58. PubMed
Hua TT, Bejoy J, Song L, Zhou Y, Li Y, & Song A (2020). Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways. Tissue Eng Part A, 27(13-14):881-893. PubMed
Huang D, Liu H, Zhu A, Zhou Y, Li Y (2020). Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior. Mol Brain, 13(1):59. PubMed
Graham K, Zhang J, Qiao H, Wu Y & Zhou Y (2019). Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice. NPJ Schizophr, 5(1):1. PubMed
Lee G, & Zhou Y (2019). NMDAR Hypofunction Animal Models of Schizophrenia. Front Mol Neurosci, 12:185. PubMed
Song L, Yuan X, Jones Z, Griffin K, Zhou Y, Ma T, Li Y (2019). Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues. Sci Rep, 9(1):5977. PubMed
Song L, Yuan X, Jones Z, Vied C, Miao Y, Marzano M, Hua T, Sang QA, Guan J, Ma T, Zhou Y, Li Y (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Sci Rep, 9(1):11055. PubMed
Badisa R, Wi S, Jones Z, Mazzio E, Zhou Y, Rosenberg J., Latinwo L, Grant S, & Goodman C (2018). Cellular and molecular responses to acute cocaine treatment in neuronal-like N2a cells: potential mechanism for its resistance in cell death. Cell Death Discov, 4:13. PubMed
Bejoy J, Song L, Zhou Y, & Li Y (2018). Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem. Tissue Eng Part A , 24(7-8):546-558. PubMed
Yan Y, Song L, Bejoy J, Kanekiyo T, Bu G, Zhou Y, & Li Y (2018). Modelling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells. Tissue Eng Part A, 24(13-14):1125-1137. PubMed
Yang S, X M, Lee E, Zhou Y, Tang H, Song H, & Zheng W (2018). Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov, 4:31. PubMed
Zhang J, & Zhou Y (2018). 14-3-3 Proteins in Glutamatergic Synapses. Neural Plast, 2018:8407609. PubMed
Wang Y, Wang YB, Sun H, Zhou A, Zhou Y & Li Y (2016). Sequential Posttranslational Modifications Regulate PKC Degradation. Molecular Biology of the Cell, 27(2):410-20. PubMed
Yan Y, Bejoy J, Xia J, Guan J, Zhou Y, Li Y (2016). Neural patterning of human induced pluripotent stem cells in 3D cultures for studing biomolecule-directed differential cellular responses. Acta Biomater, 114-26. PubMed