Dr. Yi Zhou
Professor of Biomedical Sciences & Neuroscience
- Molecular and Neurobiological Basis of Mental Disorders; Functions and Regulation of Neuronal Ion Channels.
- Current Research
- A major focus of our research is to develop and characterize animal models for the study of human neuropsychiatric diseases. We have generated a line of transgenic mice that exhibit behavioral endophenotypes corresponding to the core symptoms of schizophrenia. Using a combination of electrophysiological, biochemical and imaging approaches, we also identified schizophrenia-related synaptic deficits in the brain of our mouse model. Currently, we are using this and other mouse models to investigate the neurobiology of schizophrenia at levels of molecules, synapses and neural circuits.
- Recent Publications
Jones Z, Zhang J, Wu Y, & Zhou Y (2021). Inhibition of 14-3-3 proteins alters neural oscillations in mice. Frontiers in Neural Circuits. Front Neural Circuits , 15:647856. PubMed Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG (2020). Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Mol Cell Biol , 21(1):58. PubMed Hua TT, Bejoy J, Song L, Zhou Y, Li Y, & Song A (2020). Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways. Tissue Eng Part A, 27(13-14):881-893. PubMed Huang D, Liu H, Zhu A, Zhou Y, Li Y (2020). Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior. Mol Brain, 13(1):59. PubMed Graham K, Zhang J, Qiao H, Wu Y & Zhou Y (2019). Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice. NPJ Schizophr, 5(1):1. PubMed Lee G, & Zhou Y (2019). NMDAR Hypofunction Animal Models of Schizophrenia. Front Mol Neurosci, 12:185. PubMed Song L, Yuan X, Jones Z, Griffin K, Zhou Y, Ma T, Li Y (2019). Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues. Sci Rep, 9(1):5977. PubMed Song L, Yuan X, Jones Z, Vied C, Miao Y, Marzano M, Hua T, Sang QA, Guan J, Ma T, Zhou Y, Li Y (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Sci Rep, 9(1):11055. PubMed Badisa R, Wi S, Jones Z, Mazzio E, Zhou Y, Rosenberg J., Latinwo L, Grant S, & Goodman C (2018). Cellular and molecular responses to acute cocaine treatment in neuronal-like N2a cells: potential mechanism for its resistance in cell death. Cell Death Discov, 4:13. PubMed Bejoy J, Song L, Zhou Y, & Li Y (2018). Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem. Tissue Eng Part A , 24(7-8):546-558. PubMed Yan Y, Song L, Bejoy J, Kanekiyo T, Bu G, Zhou Y, & Li Y (2018). Modelling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells. Tissue Eng Part A, 24(13-14):1125-1137. PubMed Yang S, X M, Lee E, Zhou Y, Tang H, Song H, & Zheng W (2018). Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov, 4:31. PubMed Zhang J, & Zhou Y (2018). 14-3-3 Proteins in Glutamatergic Synapses. Neural Plast, 2018:8407609. PubMed Wang Y, Wang YB, Sun H, Zhou A, Zhou Y & Li Y (2016). Sequential Posttranslational Modifications Regulate PKC Degradation. Molecular Biology of the Cell, 27(2):410-20. PubMed Yan Y, Bejoy J, Xia J, Guan J, Zhou Y, Li Y (2016). Neural patterning of human induced pluripotent stem cells in 3D cultures for studing biomolecule-directed differential cellular responses. Acta Biomater, 114-26. PubMed
Neuro Grads and Postdocs
Meaghan Navarrete, Graduate Student