Dr. Yuan Wang is currently accepting new graduate students.
Dr. Yuan Wang
Assistant Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- We investigate the formation, dynamics, and pathology of the binaural circuit in the auditory brainstem. This circuit encodes acoustic information essential for sound and speech recognition in noisy environments, a common target across neurological disorders. We focus on the roles of the fragile X mental retardation protein (FMRP), which is responsible for the fragile X syndrome.
- Current Research
- We have four current research lines: 1) FMRP functional characterization in neuronal and circuit development in chickens using genetic manipulations; 2) FMRP function in neuronal dynamics regulated by excitatory input from the ears in mice and chickens; 3) Development of a transgenic gerbil model of fragile X syndrome for behavior studies; 4) Anatomical and biochemical studies of postmortem human brain tissues from individuals with autism and other neurological disorders.
- Recent Publications
Ma H, Yan D, Wang Y, Shi W, Liu T, Zhao C, Huo S, Duan J, Tao J, Zhai M, Luo P, Guo J, Tian L, Mageta L, Jou D, Zhang C, Li C, Lin J, Lv J, Li S, Lin L (2019). Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma. Cancer Sci, 110(3):950-961. PubMed Hong H, Wang X, Lu T, Zorio DAR, Wang Y, Sanchez JT (2018). Diverse Intrinsic Properties Shape Functional Phenotype of Low-Frequency Neurons in the Auditory Brainstem. Front Cell Neurosci, 12:175. PubMed Wang X, Zorio DAR, Schecterson L, Lu Y, Wang Y (2018). Postsynaptic FMRP Regulates Synaptogenesis In Vivo in the Developing Cochlear Nucleus. J Neurosci, 38(29):6445-6460. PubMed Sakano H, Zorio DAR, Wang X, Ting YS, Noble WS, MarCoss MJ, Rubel EW, Wang Y (2017). Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. J Comp Neurol, 525(15):3341-3359. PubMed Wang X, Hong H, Brown DH, Sanchez JT, Wang Y (2017). Distinct Neural Properties in the Low-Frequency Region of the Chicken Cochlear Nucleus Magnocellularis. eNeuro, 4(2):ENEURO.0016-17.2017. PubMed Wang Y, Zorio DAR, Karten HJ (2017). Heterogeneous organization and connectivity of the chicken auditory thalamus (Gallus gallus). J Comp Neurol, 525(14):3044-3071. PubMed Weatherstone JH, Kopp-Scheinpflug C, Pilati N, Wang Y, Forsythe ID, Rubel EW, Tempel BL (2017). Maintenance of neuronal size gradient in MNTB requires sound-evoked activity. J Neurophysiol, 117(2):756-766. PubMed Zorio DA, Jackson CM, Liu Y, Rubel EW, Wang Y (2017). Cellular distribution of the fragile X mental retardation protein in the mouse brain. J Comp Neurol, 525(4):818-849. PubMed Zorio DA, Jackson CM, Liu Y, Rubel EW, Wang Y (2016). Cellular distribution of the fragile X mental retardation protein in the mouse brain.. J Comp Neurol, 525(4):818-849. PubMed