FSU Program in Neuroscience

Interest

Dr. Yi Ren’s Lab is interested in the molecular cell biology of inflammation, especially macrophage function in CNS trauma and tumor progression.

Current Research

1. To demonstrate the pathophysiological roles of myelin-laden macrophages in SCI and provide experimental support for novel therapeutic interventions. 2. To study the underlying biologic pathways associated with stem cell-induced macrophage activation. 3. To understand the molecular basis of autism spectrum disorders (ASD) based upon large-scale gene expression profiling and to explore whether inflammatory response, particularly macrophage activation, contributes to the pathogenesis of ASD.

Recent Publications

Liu Y, Hammel G, Shi MJ, Cheng ZJ, Zivkovic S, Wang XQ, Xu PY, He XJ, Guo B, Ren Y, Zuo L (2021). Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord. Front. Cellular Neurosci, 15:651827. PubMed
Peng J, Yi MH, Jeong H, McEwan PP, Zheng J, Wu G, Ganatra S, Ren Y, Richardson JR, Oh SB, Wu LJ (2021). The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Mol Brain, 14(1):99. PubMed
Zivkovic S, Ayazi M, Hammel G, Ren Y (2021). For better or for worse: a look into neutrophils in traumatic spinal cord injury. Front. Cellular Neurosci, 15:648076. PubMed
Li JH, Sun YB, Chen WY, Fan JJ, Li SH, Qu XL, Chen QK, Chen RL, Zhu DJ, Zhang JF, Wu ZG, Chi HG, Crawford S, Oorschot V, Puelles VG, Kerr PG, Ren Y, Nilsson SK, Christian M, Tang HY, Chen W, Bertram JF, Nikolic-Paterson DJ and Yu XQ (2020). Smad4 Promotes Diabetic Nephropathy by Modulating Glycolysis and OXPHOS. EMBO Rep, 21(2):e48781. PubMed
Liu J, Zhao HQ, Zhang Q, Shi ZZ, Zhang YY, Zhao L, Ren Y, Ou RY, Xu YS (2020). Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. Exp Cell Res , 396(1):112277. PubMed
Ou R, Lv J, Zhang Q, Lin F, Zhu L, Huang F, Li X, Li T, Zhao L, Ren Y, Xu YS (2020). circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth. Mol Ther Nucleic Acids, 19:50-60. PubMed
Ou RY, Lv MF, Liu X, Lv JM, Zhao JD, Zhao Y, Li XY, Li WF, Zhao L, Li JR, Ren Y, Xu YS (2020). HPV16 E6 oncoprotein‐induced upregulation of lncRNA GABPB1‐AS1 facilitates cervical cancer progression by regulating miR‐519e‐5p/Notch2 axis. FASEB J, 34(10):13211-13223. PubMed
Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X (2019). Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol, 10:404. PubMed
Ding Z, Zhu H, Mo L, Li X, Xu R, Li T, Zhao L, Ren Y, Xu Y, Ou R (2019). FLT3L and Granulocyte Macrophage Colony-Stimulating Factor Enhance the Anti-Tumor and Immune Effects of an HPV16 E6/E7 Vaccine. Aging , 11(24):11893-11904. PubMed
Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J, Yu X (2019). Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front Pharmacol, 10:880.. PubMed
Ou R, Zhu L, Zhao L, Li W, Tao F, Lu Y, He Q, Li J, Ren Y, Xu Y (2019). HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway. J Cell Physiol, 234(3):2659-2671. PubMed
Xu Y, Zhou W, Zhang C, Liu X, Lv J, Li X, Zhao L, Li W, Li J, Ren Y, Ou R (2019). Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling. Int J Biol Macromol, 24-33. PubMed
Zhou Q, Xiang H, Li A, Lin W, Huang Z, Guo J, Wang P, Chi Y, Xiang K, Xu Y, Zhou L, So KF, Chen X, Sun X, Ren Y (2019). Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J Neurotrauma, 36(6):903-918. PubMed
Zhou T, Zheng Y, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W, Wang G, Ren Y (2019). Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci, 22(3):421-435. PubMed
Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H (2018). An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports, 11(2):348-362. PubMed
Cheng Z, Bosco DB, Sun L, Chen X, Xu Y, Tai W, Didier R, Li J, Fan J, He X, Ren Y (2017). Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery. Cell Transplant , 26(3):469-482. PubMed
Gu R, Sun X, Chi Y, Zhou Q, Xiang H, Bosco DB, Lai X, Qin C, So KF, Ren Y, Chen XM (2017). Integrin Beta3/Akt signaling contributes to platelet-induced hemangioendothelioma growth. Sci Rep, 7(1):6455. PubMed
Rolfe AJ, Bosco DB, Broussard EN, Ren Y (2017). In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages. J Vis Exp, (130):56322. PubMed
Wang ZB, Xia JF, Hoang PT, Sun L, Luo S, Cheng ZJ, Ren Y, Liu T and Guan JJ (2017). Fabrication of carbon nanotube-laden microdevices for Raman labeling of macrophages. Biomed. Phys. Eng. Express, . PubMed
Cheng Z, Zhu W, Cao K, Wu F, Li J, Wang G, Li H, Lu M, Ren Y, He X (2016). Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury. Int J Mol Sci, 17(9):1380. PubMed
Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ (2016). Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury. Cell Rep, 16(3):605-14. PubMed
Guo L, Rolfe Aj, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y (2016). Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol Brain, 9(1):48. PubMed
Jones ZB, Ren Y (2016). Sphingolipids in spinal cord injury. Int J Physiol Pathophysiol Pharmacol, 8(2):52-69. PubMed
Lai XH, Zhao LF, Chen XM, Ren Y (2016). Rapid identification and characterization of francisella by molecular biology and other techniques. Open Microbiol J, 64-77. PubMed
Rolfe AJ, Bosco DB, Wang J, Nowakowski RS, Fan J, Ren Y (2016). Bioinformatic analysis reveals the expression of unique transcriptomic signatures Zika virus infected human neural stem cells. Cell Biosci, 42. PubMed
Sun X, Jones ZB, Chen XM, Zhou L, So KF, Ren Y (2016). Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J Neuroinflammation , 260. PubMed
Xia J, Wang Z, Yan Y, Cheng Z, Sun L, Li Y, Ren Y, Guan J (2016). Catalese-laden microdevices for cell-mediated enzyme delivery . Langmuir, 32(50):13386-13393. PubMed
He GR, Zhang HZ, Chen CD, Lai XH, Ren Y, and Chen XM (2013). Adoptive transfer of glypican-3 peptide-specific CD8 T lymphocytes causes regression of testicular yolk sac tumor in mice. Int. J. Innovat. Res. Med. Sci, 1(09):345-353.

Accepting new graduate students.

Dr. Yi Ren

Professor of Biomedical Sciences & Neuroscience

Faculty

Biomedical Sciences

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644-3076

yren@neuro.fsu.edu

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Lab Website

Neuro Grads and Postdocs