FSU Program in Neuroscience

Interest

Dr. Yi Ren’s Lab is interested in the molecular cell biology of inflammation, especially macrophage function in CNS trauma and tumor progression.

Current Research

1. To demonstrate the pathophysiological roles of myelin-laden macrophages in SCI and provide experimental support for novel therapeutic interventions. 2. To study the underlying biologic pathways associated with stem cell-induced macrophage activation. 3. To understand the molecular basis of autism spectrum disorders (ASD) based upon large-scale gene expression profiling and to explore whether inflammatory response, particularly macrophage activation, contributes to the pathogenesis of ASD.

Recent Publications

Xu Y, Zhou W, Zhang C, Liu X, Lv J, Li X, Zhao L, Li W, Li J, Ren Y, Ou R (20119). Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling. Int J Biol Macromol, 24-33. PubMed
Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X (2019). Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol, 10:404. PubMed
Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J, Yu X (2019). Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front Pharmacol, 10:880.. PubMed
Ou R, Lv J, Zhang Q, Lin F, Zhu L, Huang F, Li X, Li T, Zhao L, Ren Y, Xu Y (2019). circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth.. Mol Ther Nucleic Acids, 50-60. PubMed
Ou R, Zhu L, Zhao L, Li W, Tao F, Lu Y, He Q, Li J, Ren Y, Xu Y (2019). HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway. J Cell Physiol, 234(3):2659-2671. PubMed
Wang B, Qin W, Ren Y, Zhou X, Jung MY, Han P, Eloe-Fadrosh EA, Li M, Zheng Y, Lu L, Yan X, Ji J, Liu Y, Liu L, Heiner C, Hall R, Martens-Habbena W, Herbold CW, Rhee SK, Bartlett DH, Huang L, Ingalls AE, Wagner M, Stahl DA, Jia Z (2019). Expansion of Thaumarchaeota habitat range is correlated with horizontal transfer of ATPase operons. ISME J, 13(12):3067-3079. PubMed
Zhou Q, Xiang H, Li A, Lin W, Huang Z, Guo J, Wang P, Chi Y, Xiang K, Xu Y, Zhou L, So KF, Chen X, Sun X, Ren Y (2019). Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J Neurotrauma, 36(6):903-918. PubMed
Zhou T, Zheng Y, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W, Wang G, Ren Y (2019). Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci, 22(3):421-435. PubMed
Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H (2018). An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports, 11(2):348-362. PubMed
Cheng Z, Bosco DB, Sun L, Chen X, Xu Y, Tai W, Didier R, Li J, Fan J, He X, Ren Y (2017). Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery. Cell Transplant , 26(3):469-482. PubMed
Gu R, Sun X, Chi Y, Zhou Q, Xiang H, Bosco DB, Lai X, Qin C, So KF, Ren Y, Chen XM (2017). Integrin Beta3/Akt signaling contributes to platelet-induced hemangioendothelioma growth. Sci Rep, 7(1):6455. PubMed
Rolfe AJ, Bosco DB, Broussard EN, Ren Y (2017). In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages. J Vis Exp, (130):56322. PubMed
Cheng Z, Zhu W, Cao K, Wu F, Li J, Wang G, Li H, Lu M, Ren Y, He X (2016). Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury. Int J Mol Sci, 17(9):1380. PubMed
Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ (2016). Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury. Cell Rep, 16(3):605-14. PubMed
Guo L, Rolfe Aj, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y (2016). Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol Brain, 9(1):48. PubMed
Jones ZB, Ren Y (2016). Sphingolipids in spinal cord injury. Int J Physiol Pathophysiol Pharmacol, 8(2):52-69. PubMed
Lai XH, Zhao LF, Chen XM, Ren Y (2016). Rapid identification and characterization of francisella by molecular biology and other techniques. Open Microbiol J, 64-77. PubMed
Rolfe AJ, Bosco DB, Wang J, Nowakowski RS, Fan J, Ren Y (2016). Bioinformatic analysis reveals the expression of unique transcriptomic signatures Zika virus infected human neural stem cells. Cell Biosci, 42. PubMed
Sun X, Jones ZB, Chen XM, Zhou L, So KF, Ren Y (2016). Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J Neuroinflammation , 260. PubMed
Xia J, Wang Z, Yan Y, Cheng Z, Sun L, Li Y, Ren Y, Guan J (2016). Catalese-laden microdevices for cell-mediated enzyme delivery . Langmuir, 32(50):13386-13393. PubMed
Qu X, Jiang M, Sun YB, Jiang X, Fu P, Ren Y, Wang D, Dai L, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J (2015). The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction. Kidney Int, 88(6):1323-1335. PubMed
Sun YB, Qu X, Howard V, Dai L, Jiang X, Ren Y, Fu P, Puelles VG, Nikolic-Paterson DJ, Caruana G, Bertram JF, Sleeman MW, Li J (2015). Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance. Kidney Int, 88(2):286-98. PubMed
Wang X, Cao K, Sun X, Chen Y, Duan Z, Sun L, Guo L, Bai P, Sun D, Fan J, He X, Young W, Ren Y (2015). Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia, 63(4):635-51. PubMed
Yao XM, Chen ZL, Shen DL, Zhou QS, Huang SS, Cai ZR, Tong YL, Wang M, Ren Y, Lai XH, Chen XM (2015). Risk factors for pediatric intussusception complicated by loss of intestine viability in China from June 2009 to May 2014: a retrospective study. Pediatr Surg Int, 31(2):163-6. PubMed

Dr. Yi Ren

Professor of Biomedical Sciences & Neuroscience

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Neuro Grads and Postdocs