Dr. Timothy Megraw is currently accepting new graduate students.
Dr. Timothy Megraw
Associate Professor of Biomedical Sciences & Neuroscience
- Faculty
- Biomedical Sciences
- MSR 3300
- 645-9271
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tmegraw@neuro.fsu.edu
- Interest
- The Megraw lab investigates the functions of centrosomes and cilia in cell division, development and disease using Drosophila, mouse, and human cell culture models. This includes asymmetric division of stem cells, the regulation of centrosomal and other microtubule-organizing centers (MTOCs), metabolic disorders due to loss of centrosome proteins, and regulation of primary cilium assembly and function. Centrosome-based disorders that impact stem cell function and brain development are a major focus of our research.
- Current Research
- The centrosome is the major microtubule-organizing center (MTOC) in animal cells and impacts many disease-related functions. We focus on the links between centrosome functions and inherited forms of microcephaly that arise from syndromes such as MCPH or SCKL. Our investigations show cell division-related defects in stem cells arising from impaired centrosome replication, but there are also specific metabolic impairments in cells mutant for centrosome protein genes. We suspect that Zika virus perturbs the same centrosome-related pathways in human neural stem cells, causing microcephaly in infected mothers during their pregnancy. We are investigating the links between Zika virus infection and centrosome impairment, to connect the inherited and viral-induced forms of microcephaly.
- Recent Publications
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Blake-Hedges C, Megraw TL (2019). Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster. Results Probl Cell Differ, 277-321. PubMed Ghoveud E, Teimuri S, Vatandoost J, Hosseini A, Ghaedi K, Etemadifar M, Nasr Esfahani MH, Megraw TL (2019). Potential Biomarker and Therapeutic LncRNAs in Multiple Sclerosis Through Targeting Memory B Cells. Neuromolecular Med, 22(1):111-120. PubMed Hosseini A, Teimuri S, Ehsani M, Rasa SMM, Etemadifar M, Nasr Esfahani MH, Megraw TL, Ghaedi K (2019). LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage. J Cell Physiol, 234(12):22153-22162. PubMed Zhou T, Zheng Y, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W, Wang G, Ren Y (2019). Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci, 22(3):421-435. PubMed Teimuri S, Hosseini A, Rezaenasab A, Ghaedi K, Ghoveud E, Etemadifar M, Nasr-Esfahani MH, Megraw TL (2018). Integrative Analysis of lncRNAs in Th17 Cell Lineage to Discover New Potential Biomarkers and Therapeutic Targets in Autoimmune Diseases. Mol Ther Nucleic Acids, 393-404. PubMed Tillery MML, Blake-Hedges C, Zheng Y, Buchwalter RA, Megraw TL (2018). Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster. Cells, 7(9):121. PubMed Chen JV, Buchwalter RA, Kao LR, Megraw TL (2017). A splice variant of centrosomin converts mitochondria to microtubule- organizing centers. Curr Biol, 27(13):1928-1940. PubMed Manojlovic Z, Earwood R, Kato A, Perez D, Cabrera OA, Didier R, Megraw TL, Stefanovic B, Kato Y (2017). La-related protein 6 controls ciliated cell differentiation . Cilia, 6:4. PubMed Debec A, Megraw TL, Guichet A (2016). Methods to establish drosophila cell lines. Methods Mol Biol, 333-351. PubMed Guarderas F, Leavell Y, Sengupta T, Zhukova M, Megraw TL (2016). Assessment of Chicken-Egg Membrane as a Dressing for Wound Healing. Adv Skin Wound Care, 29(3):131-4. PubMed Jana SC, Bettencourt-Dias M, Durand B, Megraw TL. (2016). Drosophila melanogaster as a model for basal body research.. Cilia, 5:22. PubMed Jodeiri Farshbaf M, Ghaedi K, Megraw TL, Curtiss J, Shirani Faradonbeh M, Vaziri P, Nasr-Esfahani MH (2016). Does PGC1alpha/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?. Neuromolecular Med, 18(1):1-15. PubMed Zheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard D, Megraw TL (2016). The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila.. Mol Biol Cell, 27(11):1740-52. PubMed Bingol K, Li DW, Bruschweiler-Li L, Cabrera OA, Megraw T, Zhang F, Brüschweiler R (2015). Unified and isomer-specific NMR metabolomics database for the accurate analysis of (13)C-(1)H HSQC spectra. ACS Chem Biol, 10(2):452-9. PubMed Chen JV, Kao LR, Jana SC, Sivan-Loukianova E, Mendonça S, Cabrera OA, Singh P, Cabernard C, Eberl DF, Bettencourt-Dias M, Megraw TL (2015). Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. J Cell Biol, 211(2):435-53. PubMed Man X, Megraw TL, Lim YP (2015). Cep68 can be regulated by Nek2 and SCF complex. Eur J Cell Biol, 94(3-4):162-72. PubMed Tözser J, Earwood R, Kato A, Brown J, Tanaka K, Didier R, Megraw TL, Blum M, Kato Y (2015). TGF-beta Signaling Regulates the Differentiation of Motile Cilia. Cell Rep, 11(7):1000-7. PubMed
All Publications
Lab Website
Neuro Grads and Postdocs
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Caitlyn Blake-Hedges, Graduate Student - Biomedical sciences |
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Rebecca Buchwalter, Graduate Student - Biomedical sciences |
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Ling-Rong Kao, Affiliate - Biomedical sciences |
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Marisa Tillery, Graduate Student - Biomedical sciences |
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Elise Wight, Graduate Student - Biomedical sciences |
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Chunfeng Zheng, Lab Tech |