Florida State University

Dr. Sanjay Kumar

Associate Professor of Biomedical Sciences & Neuroscience

Faculty
Biomedical Sciences
MSR 3300B
645-8336

kumar@neuro.fsu.edu

Interest
Neuronal Plasticity, Receptor Biophysics, Temporal Lobe Epilepsy.
Current Research
Basic research in the Kumar laboratory is focused on synaptic physiology underlying neocortical function and plasticity. We are particularly interested in understanding the workings and role of glutamatergic AMPA and N-methyl-D-aspartate Receptors in these processes. Translational research efforts of the lab are focused on deciphering basic pathophysiological mechanisms underlying Temporal Lobe Epilepsy, the most common type of epilepsy in adults. Here, we seek to identify / isolate ictogenic cells and circuits within the parahippocampal region for the purposes of developing therapeutic / interventional strategies to combat TLE. We use a variety of tools and techniques with electrophysiology being the mainstay of our research.
Recent Publications
Beesley S, Sullenberger T, Crotty K, Ailani R, D'Orio C, Evans K, Ogunkunle EO, Roper MG, Kumar SS (2020). D-serine mitigates cell loss associated with temporal lobe epilepsy. Nat Commun, 11(1):4966. PubMed
Beesley S, Sullenberger T, Kumar SS (2020). The GluN3 subunit regulates ion selectivity within native N-methyl-d-aspartate receptors. IBRO Rep, 9:147-156. PubMed
Beesley S, Sullenberger T, Pilli J, Abbasi S, Gunjan A, Kumar SS (2019). Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex. J Neurophysiol, 121(1):238-254. PubMed
Sullenberger T, Don H, Kumar SS (2019). Functional Connectivity of the Parasubiculum and Its Role in Temporal Lobe Epilepsy. Neuroscience, 410:217-238. PubMed
Abbasi S, Kumar SS (2015). Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy. J Neurophysiol, 114(5):2854-66. PubMed
Abbasi S, Kumar SS (2015). Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy. J Neurophysiol, 114(5):2854-66. PubMed
Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB (2015). N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells. PLoS One, 10(1):e0114285. PubMed
Abbasi S, Kumar SS (2014). Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy. J Neurophysiol, 112(11):2888-900. PubMed
O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J (2014). Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance. Neuroscience, 277:506-21. PubMed
Pilli J, Kumar SS (2014). Potentiation of convergent synaptic inputs onto pyramidal neurons in somatosensory cortex: dependence on brain wave frequencies and NMDA receptor subunit composition. Neuroscience, 272:271-85. PubMed
Abbasi S, Kumar SS (2013). Electrophysiological and morphological characterization of cells in superficial layers of rat presubiculum. J Comp Neurol, 521(13):3116-32. PubMed
Pilli J, Abbasi S, Richardson M, Kumar SS (2012). Diversity and excitability of deep-layer entorhinal cortical neurons in a model of temporal lobe epilepsy. J Neurophysiol, 108(6):1724-38. PubMed
Pilli J, Kumar SS (2012). Triheteromeric N-methyl-D-aspartate receptors differentiate synaptic inputs onto pyramidal neurons in somatosensory cortex: involvement of the GluN3A subunit. Neuroscience, 222:75-88. PubMed
Kumar SS, Buckmaster PS (2007). Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulata. Brain Res, 1142:54-60. PubMed
Kumar SS, Jin X, Buckmaster PS, Huguenard JR (2007). Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci, 27(6):1239-46. PubMed
Kumar SS, Buckmaster PS (2006). Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci, 26(17):4613-23. PubMed
Kumar SS, Wen X, Yang Y, Buckmaster PS (2006). GABAA receptor-mediated IPSCs and alpha1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy. J Neurophysiol, 95(4):2446-55. PubMed
Kumar SS, Huguenard JR (2003). Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci, 23(31):10074-83. PubMed
Kumar SS, Bacci A, Kharazia V, Huguenard JR (2002). A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci, 22(8):3005-15. PubMed
Kumar SS, Huguenard JR (2001). Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex. J Neurophysiol, 86(6):2973-85. PubMed
Kumar SS, Faber DS (1999). Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. J Neurosci, 19(5):1620-35. PubMed
Silva A, Kumar S, Pereda A, Faber DS (1995). Regulation of synaptic strength at mixed synapses: effects of dopamine receptor blockade and protein kinase C activation. Neuropharmacology, 34(11):1559-65. PubMed
Kumar SS, Geuz A (1991). Adaptive Resonance Theory based adaptive pole placement for neurocontrollers. Neural Networks, 4:319-335.
Komuro H, Obaid AL, Kumar SS, Salzberg BM (1990). Slices of mouse suprachiasmatic nucleus with attached optic nerve: recording of glutaminergic and GABA-ergic synaptic potentials using a voltage sensitive dye. Biological Bulletin, 179(2):231.
Obaid AL, Komuro H, Kumar SS, Sugimori M, Lin JW, Cherkskey BD, Llinas R, Salzberg BM (1990). FTX, an HPLC-purified fraction of funnel web spider venom, blocks calcium channels required for normal release in peptidergic nerve terminals of mammals: optical measurements with and without voltage sensitive dyes. Biological Bulletin, 179(2):232.

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Matthew Crockett, Graduate Student

Thomas Sullenberger, Graduate Student

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