Dr. Jian Feng
Assistant Professor of Biological Science & Neuroscience
- Faculty
- Biological Science
- KIN 3061
- 644-3706
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feng@bio.fsu.edu
- Interest
- Epigenetic regulation of neuropsychiatric disorders.
- Current Research
- Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
- Recent Publications
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Chitaman JM, Fraser P, Feng J (2019). Three-dimensional chromosome architecture and drug addiction. Curr Opin Neurobiol, 137-145. PubMed Brown AN, Feng J (2017). Drug Addiction and DNA Modifications. Adv Exp Med Biol, 105-125. PubMed Hu Q, Kim EJ, Feng J, Grant GR, Heller EA (2017). Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain. PLoS Comput Biol, 13(6):e1005602. PubMed Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A (2017). Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Sci Rep, 7(1):11082. PubMed Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ (2014). Beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature, 516(7529):51-5. PubMed Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L. (2014). Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. Genome Biology, 15(4):R65. PubMed Feng J, Nestler EJ. (2013). Epigenetic mechanisms of drug addiction. Curr Opin Neurobiol, 23(4):521-8. PubMed Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ (2013). Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci, 16(4):434-40. PubMed Vialou V, Feng J, Robison AJ, Nestler EJ (2013). Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol, 59-87. PubMed Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ (2011). Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci U S A, 108(7):3035-40. PubMed Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G (2010). Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci, 13(4):423-30. PubMed
All Publications
Lab Website
Neuro Grads and Postdocs
|
Javed Chitaman, Graduate Student |
|
Rahul Jasrotia, Postdoctoral Associate |
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Graham Kaplan, Graduate Student |
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Yuxiang Li, Postdoctoral Associate |
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Colton Remedies, Graduate Student |
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Nicholas Wadell, Graduate Student - Biological science |
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Haiyang Xu, Postdoctoral Associate |