Jian Feng
Interest
Epigenetic regulation of neuropsychiatric disorders.
Current Research
Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
Chitaman JM, Fraser P, Feng J (2019). Three-dimensional chromosome architecture and drug addiction. Curr Opin Neurobiol, 137-145. PubMed
Brown AN, Feng J (2017). Drug Addiction and DNA Modifications. Adv Exp Med Biol, 105-125. PubMed
Hu Q, Kim EJ, Feng J, Grant GR, Heller EA (2017). Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain. PLoS Comput Biol, 13(6):e1005602. PubMed
Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A (2017). Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Sci Rep, 7(1):11082. PubMed