Florida State University

Dr. Jian Feng

Assistant Professor of Biological Science & Neuroscience

Biological Science
KIN 3061


Epigenetic regulation of neuropsychiatric disorders.
Current Research
Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
Recent Publications
Chitaman JM, Fraser P, Feng J (2019). Three-dimensional chromosome architecture and drug addiction. Curr Opin Neurobiol, 137-145. PubMed
Brown AN, Feng J (2017). Drug Addiction and DNA Modifications. Adv Exp Med Biol, 105-125. PubMed
Hu Q, Kim EJ, Feng J, Grant GR, Heller EA (2017). Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain. PLoS Comput Biol, 13(6):e1005602. PubMed
Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A (2017). Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Sci Rep, 7(1):11082. PubMed
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ (2014). Beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature, 516(7529):51-5. PubMed
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L. (2014). Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. Genome Biology, 15(4):R65. PubMed
Feng J, Nestler EJ. (2013). Epigenetic mechanisms of drug addiction. Curr Opin Neurobiol, 23(4):521-8. PubMed
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ (2013). Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci, 16(4):434-40. PubMed
Vialou V, Feng J, Robison AJ, Nestler EJ (2013). Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol, 59-87. PubMed
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ (2011). Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci U S A, 108(7):3035-40. PubMed
Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G (2010). Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci, 13(4):423-30. PubMed

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Javed Chitaman, Graduate Student

Rahul Jasrotia, Postdoctoral Associate

Graham Kaplan, Graduate Student

Yuxiang Li, Postdoctoral Associate

Colton Remedies, Graduate Student

Nicholas Wadell, Graduate Student - Biological science

Haiyang Xu, Postdoctoral Associate

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