Florida State University

Dr. Jian Feng is currently accepting new graduate students.


Dr. Jian Feng

Assistant Professor of Biological Science & Neuroscience

Biological Science
KIN 3061


Epigenetic regulation of neuropsychiatric disorders.
Current Research
Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
Recent Publications
Chitaman JM, Fraser P, Feng J, Three-dimensional chromosome architecture and drug addiction, Curr Opin Neurobiol, 2019 PubMed
Hu Q, Kim EJ, Feng J, Grant GR, Heller EA, Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain, PLoS Comput Biol, 2017 PubMed
Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A, Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain, Sci Rep, 2017 PubMed
Brown AN, Feng J, Drug Addiction and DNA Modifications, Adv Exp Med Biol, 2017 PubMed
Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ, Role of Tet1 and 5-hydroxymethylcytosine in cocaine action, Nat Neurosci, 2015 PubMed
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ, Beta-catenin mediates stress resilience through Dicer1/microRNA regulation, Nature, 2014 PubMed
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L., Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens, Genome Biology, 2014 PubMed
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ, Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation, Nat Neurosci, 2013 PubMed
Feng J, Nestler EJ., Epigenetic mechanisms of drug addiction, Curr Opin Neurobiol, 2013 PubMed
Vialou V, Feng J, Robison AJ, Nestler EJ, Epigenetic mechanisms of depression and antidepressant action, Annu Rev Pharmacol Toxicol, 2013 PubMed
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ, Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens, Proc Natl Acad Sci U S A, 2011 PubMed
Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G, Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons, Nat Neurosci, 2010 PubMed

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Javed Chitaman, Graduate Student

Rachel Hedinger, Graduate Student

Rahul Jasrotia, Postdoctoral Associate

Graham Kaplan, Graduate Student

Yuxiang Li, Postdoctoral Associate

Nicholas Wadell, Graduate Student - Biological science

Haiyang Xu, Postdoctoral Associate

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