Dr. James Fadool is currently accepting new graduate students.
Dr. James Fadool
Professor of Biological Science & Neuroscience
- Biological Science
- KIN 3018
- Retinal Development, Photoreceptor Degeneration, Regeneration, Synaptic Plasticity, Zebrafish Genetics
- Current Research
- Have you ever wondered what controls the development of the nervous system? What genes regulated the number and types of neurons generated during development? What guides formation of the synapse? How the brain responds to injury? What allows some species retain the capacity for neural regeneration and regain function but limits our own capacity for repair? The zebrafish visual system offers many advantages as a model system to answer these questions. Retinal anatomy, physiology and development are highly conserved in virtually all vertebrates. The zebrafish retina is cone-dominated like our fovea, and the cones are arranged in a highly ordered mosaic. In our work, we combine a variety of approaches spanning embryological manipulations and behavior, to forward genetic screens, genome-editing, transgenesis, and live confocal imaging.
- Recent Publications
Zelinka CP, Sotolongo-Lopez M, Fadool JM (2018). Targeted disruption of the endogenous zebrafish rhodopsin locus as models of rapid rod photoreceptor degeneration. Mol Vis, 587-602. PubMed Kovach CP, Al Koborssy D, Huang Z, Chelette BM, Fadool JM, Fadool DA (2016). Mitochondrial ultrastructure and glucose signaling pathways attributed to the Kv1.3 ion channel. Frontiers in Physiology, 178. PubMed Sotolongo-Lopez M, Alvarez-Delfin K, Saade CJ, Vera DL, Fadool JM (2016). Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish. PLoS Genet, . PubMed Taylor SM, Alvarez-Delfin K, Saade CJ, Thomas JL, Thummel R, Fadool JM, Hitchcock PF (2015). The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling. Invest Ophthalmol Vis Sci, 56(12):7496-515. PubMed