Florida State University

Dr. Thomas Houpt

Professor of Biological Science & Neuroscience

Biological Science
KIN 3010


Molecular neurobiology of conditioned taste aversion and ingestive behavior.
Current Research
The taste and smell of food can evoke strong memories. The strength and importance of food-learning makes it a good system to explore the behavior, neurology, and molecular biology of learning and memory. I use a simple but robust model of learning: conditioned taste aversion, in which rats learn to reject a palatable solution after it is paired with a toxin (LiCl). Behavioral studies are combined with brain lesions, neuroanatomical imaging, and single-cell RNA amplification to study the patterns of gene expression underlying long-term changes in the rat's ingestive behavior.
Recent Publications
Houpt TA, Kwon B, Houpt CE, Neth B, Smith JC, Orientation within a high magnetic field determines swimming direction and laterality of c-Fos induction in mice, Am J Physiol Regul Integr Comp Physiol, 2013 PubMed
Torregrossa AM, Bales MB, Breza JM, Houpt TA, Smith JC, Contreras RJ, Water restriction and fluid temperature alter preference for water and sucrose solution, Chem Senses, 2012 PubMed
Houpt TA, Cassell J, Carella L, Neth B, Smith JC, Head tilt in rats during exposure to a high magnetic field, Physiol Behav, 2012 PubMed
Spencer CM, Eckel LA, Nardos R, Houpt TA, Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning, Physiol Behav, 2012 PubMed
Kwon B, Houpt TA, Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning, Neurobiol Learn Mem, 2012 PubMed
Kimbrough A, Kwon BS, Eckel LA, Houpt TA, Systemic 5-bromo-2-deoxyuridine induces conditioned flavor aversion and c-Fos in the visceral neuraxis, Learn Mem, 2011 PubMed
Cason AM, Kwon B, Smith JC, Houpt TA, Labyrinthectomy abolishes the behavioral and neural response of rats to a high-strength static magnetic field, Physiol Behav, 2009 PubMed
Davenport RA, Houpt TA, D-cycloserine enhances short-delay, but not long-delay, conditioned taste aversion learning in rats, Pharmacol Biochem Behav, 2009 PubMed
Kwon B, Goltz M, Houpt TA, Expression of AP-1 family transcription factors in the amygdala during conditioned taste aversion learning: role for Fra-2, Brain Res, 2008 PubMed
Houpt TA, Cassell JA, Riccardi C, Kwon B, Smith JC, Suppression of drinking by exposure to a high-strength static magnetic field, Physiol Behav, 2007 PubMed
Davila NG, Houpt TA, Trombley PQ, Expression and function of kainate receptors in the rat olfactory bulb, Synapse, 2007 PubMed
Houpt TA, Cassell JA, Riccardi C, DenBleyker MD, Hood A, Smith JC, Rats avoid high magnetic fields: dependence on an intact vestibular system, Physiol Behav, 2007 PubMed
Houpt TA, Cassell JA, Cason AM, Riedell A, Golden GJ, Riccardi C, Smith JC, Evidence for a cephalic site of action of high magnetic fields on the behavioral responses of rats, Physiol Behav, 2007 PubMed
Nunnink M, Davenport RA, Ortega B, Houpt TA, D-Cycloserine enhances conditioned taste aversion learning in rats, Pharmacol Biochem Behav, 2007 PubMed
Golden GJ, Houpt TA, NMDA receptor in conditioned flavor-taste preference learning: blockade by MK-801 and enhancement by D-cycloserine, Pharmacol Biochem Behav, 2007 PubMed
Cason AM, Denbleyker M, Ferrence K, Smith JC, Houpt TA, Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids, Am J Physiol Regul Integr Comp Physiol, 2006 PubMed
Spencer CM, Jahng JW, Ryu V, Houpt TA, Lithium-induced gene expression of inducible cyclic adenosine monophosphate early repressor in the rat adrenal gland, J Neurosci Res, 2005 PubMed
Houpt TA, Pittman DW, Riccardi C, Cassell JA, Lockwood DR, Barranco JM, Kwon B, Smith JC, Behavioral effects on rats of high strength magnetic fields generated by a resistive electromagnet, Physiol Behav, 2005 PubMed
Jahng JW, Spencer CM, Choi SH, Kim DG, Houpt TA, Nitric oxide is involved in lithium-induced immediate early gene expressions in the adrenal medulla, Eur J Pharmacol, 2004 PubMed
Jahng JW, Lee JH, Lee S, Lee JY, Kim GT, Houpt TA, Kim DG, N(omega)-nitro-L-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats, Neurosci Res, 2004 PubMed
Horning MS, Kwon B, Blakemore LJ, Spencer CM, Goltz M, Houpt TA, Trombley PQ, Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunit expression in rat olfactory bulb, Neurosci Lett, 2004 PubMed
Jahng JW, Lee JH, Kim GT, Kim YM, Houpt TA, Kim DG, Adrenalectomy abolishes fasting-induced down-regulation of NADPH-diaphorase in the rat paraventricular nucleus, Yonsei Med J, 2004 PubMed

All Publications PubMed

Lab Website

Training Grant Opportunities

Neuro Grads and Postdocs

Marena Bass, Graduate Student

Jason Cote, Graduate Student

Durba Mukherjee, Graduate Student

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