Accepting new graduate students.
Dr. Douglas Storace
Assistant Professor in Biology and Neuroscience
- Perception, decision making and behavior depend on detecting and responding appropriately to sensory information. However, the mechanisms employed by the brain to encode sensory information, and how those signals are transformed into meaningful information that we perceive and act on remains largely unknown. My laboratory investigates this central problem in neuroscience using the mouse olfactory bulb as a model system. By combining neural recording techniques with behavior, we can pursue key questions in olfactory perception. For example, why does our perception of an odor fade when under constant exposure? How can we recognize odors in dynamic and noisy environments? How does our brain bind odor stimuli into perceptual objects that we can recognize and make associations with? How does internal state influence the processing of sensory information? Having a comprehensive characterization how the brain transforms sensory input into perception and behavior will yield fundamental insight into the basic processes by which the entire brain functions.
- Current Research
- Sensory processing, function and organization of neural circuits, imaging brain activity.
- Recent Publications
Martelli C, Storace DA (2021). Stimulus Driven Functional Transformations in the Early Olfactory System. Front Cell Neurosci, 15:684742. PubMed Storace DA, Cohen LB (2021). The mammalian olfactory bulb contributes to the adaptation of odor responses: a second perceptual computation carried out by the bulb. eNeuro, 0322-21. PubMed Oltmanns S, Abben FS, Ender A, Aimon S, Kovacs R, Sigrist SJ, Storace DA, Geiger JRP, Raccuglia D (2020). NOSA, an Analytical Toolbox for Multicellular Optical Electrophysiology. Front Neurosci, 14:712. PubMed Storace DA, Cohen LB, Choi Y (2019). Using Genetically Encoded Voltage Indicators (GEVIs) to Study the Input-Output Transformation of the Mammalian Olfactory Bulb. Front Cell Neurosci, 13:342. PubMed Sepehri Rad M, Choi Y, Cohen LB, Baker BJ, Zhong S, Storace DA, Braubach OR (2017). Voltage and Calcium Imaging of Brain Activity. Biophys J, 113(10):2160-2167. PubMed Storace DA, Cohen LB (2017). Measuring the olfactory bulb input-output transformation reveals a contribution to the perception of odorant concentration invariance. Nat Commun, 8(1):81. PubMed
Neuro Grads and Postdocs
Meizhu Qi, Graduate Student