Dr. Debra Ann Fadool is currently accepting new graduate students.
Dr. Debra Ann Fadool
Nancy Marcus Professor of Biological Science, Director of Chemical Senses Training Grant Program
- Faculty
- Biological Science
- KIN 3008
- 644-4775
-
dafadool@neuro.fsu.edu
- Interest
- Olfactory Signal Transduction and Neuromodulation of Ion Channels.
- Current Research
- We have discovered that hormones and neurotrophins [glucagon-like peptide 1 (glp-1), insulin, and brain-derived neurotrophic factor (BDNF)] modulate electrical activity in the brain at the level of the ion channel via phosphorylation. These types of signaling molecules are also involved in maintaining energy homeostasis. Currently, we hypothesize that the olfactory system not only senses our external chemical environment (odors) but is a detector of internal chemistry, the chemistry of metabolism. As such, we are studying the neuropathology of diabetes and obesity - how sensory systems, such as the olfactory system are perturbed by diet-induced obesity at the level of the ion channel using electrophysiology, nanotechnology, and optogenetics. I serve also as the director of our NIH Chemical Senses Training Grant, for which predoctoral students and postdoctoral scholars can read about special training opportunities (see link above right).
- Recent Publications
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Al Koborssy D, Palouzier-Paulignan B, Canova V, Thevenet M, Fadool DA, Julliard AK (2019). Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex. Brain Struct Funct, 224(1):315-336. PubMed Chelette BM, Thomas AM, Fadool DA (2019). Long-term obesogenic diet and targeted deletion of potassium channel Kv 1.3 have differing effects on voluntary exercise in mice. Physiol Rep, 7(20):e14254. PubMed Fardone E, Celen AB, Schreiter NA, Thiebaud N, Cooper ML, Fadool DA (2019). Loss of odor-induced c-Fos expression of juxtaglomerular activity following maintenance of mice on fatty diets. J Bioenerg Biomembr, 51(1):3-13. PubMed Thiebaud N, Gribble F, Reimann F, Trapp S, Fadool DA (2019). A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Sci Rep, 9(1):15542. PubMed Huang Z, Hoffman CA, Chelette BM, Thiebaud N, Fadool DA (2018). Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice. Front Behav Neurosci, 12:49. PubMed Bell GA, Fadool DA (2017). Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice. Physiol Behav, 104-113. PubMed Huang Z, Thiebaud N, Fadool DA (2017). Differential serotonergic modulation across the main and accessory olfactory bulbs. J Physiol, 595(11):3515-3533. PubMed Julliard AK, Al Koborssy D, Fadool DA, Palouzier-Paulignan B (2017). Nutrient sensing: Another chemosensitivity of the olfactory system. Front Physiol, 468. PubMed Schwartz AB, Kapur A, Wang W, Huang Z, Fardone E, Palui G, Mattoussi H, Fadool DA (2017). Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3. J Neurochem, 140(3):404-420. PubMed Kovach CP, Al Koborssy D, Huang Z, Chelette BM, Fadool JM, Fadool DA (2016). Mitochondrial ultrastructure and glucose signaling pathways attributed to the Kv1.3 ion channel. Front Physiol, 178. PubMed McCarthy DM, Bell GA, Cannon EN, Mueller KA, Huizenga MN, Sadri-Vakili G, Fadool DA, Bhide PG (2016). Reversal learning deficits associated with increased frontal cortical brain-derived neurotrophic factor tyrosine kinase B signaling in a prenatal cocaine exposure mouse model. Dev Neurosci, 38(5):354-364. PubMed Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA (2016). The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. J Physiol, 594(10):2607-28. PubMed Velez P, Schwartz AB, Iyer SR, Warrington A, Fadool DA (2016). Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting. J Neurophysiol, 116(2):671-85. PubMed Spear JM, Koborssy DA, Schwartz AB, Johnson AJ, Audhya A, Fadool DA, Stagg SM (2015). Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a. BMC Biochem, 16:16. PubMed
All Publications
Lab Website
Training Grant Opportunities
Neuro Grads and Postdocs
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Brandon Chelette, Graduate Student |
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Louis Colling, Graduate Student - Biological science |
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Destinee Gatlin, Graduate Student - Biological science |
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Daniel Landi Conde, Graduate Student |
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Ashley Loeven, Graduate Student - Biological science |
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Meizhu Qi, Graduate Student |
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Nicolas Thiebaud, Affiliate - Biological science |