Debra Ann Fadool
Contact Information
Interest
Olfactory Signal Transduction and Neuromodulation of Ion Channels.
Current Research
We have discovered that hormones and neurotrophins [glucagon-like peptide 1 (glp-1), insulin, and brain-derived neurotrophic factor (BDNF)] modulate electrical activity in the brain at the level of the ion channel via phosphorylation. These types of signaling molecules are also involved in maintaining energy homeostasis. Currently, we hypothesize that the olfactory system not only senses our external chemical environment (odors) but is a detector of internal chemistry, the chemistry of metabolism. As such, we are studying the neuropathology of diabetes and obesity - how sensory systems, such as the olfactory system are perturbed by diet-induced obesity at the level of the ion channel using electrophysiology, nanotechnology, and optogenetics. I serve also as the director of our NIH Chemical Senses Training Grant, for which predoctoral students and postdoctoral scholars can read about special training opportunities.
Fadool DA and Kolling LJ (2020). Role of olfaction for eating behavior. Academic Press, 675–716.
Al Koborssy D, Palouzier-Paulignan B, Canova V, Thevenet M, Fadool DA, Julliard AK (2019). Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex. Brain Struct Funct, 224(1):315-336. PubMed
Chelette BM, Thomas AM, Fadool DA (2019). Long-term obesogenic diet and targeted deletion of potassium channel Kv 1.3 have differing effects on voluntary exercise in mice. Physiol Rep, 7(20):e14254. PubMed
Fardone E, Celen AB, Schreiter NA, Thiebaud N, Cooper ML, Fadool DA (2019). Loss of odor-induced c-Fos expression of juxtaglomerular activity following maintenance of mice on fatty diets. J Bioenerg Biomembr, 51(1):3-13. PubMed
Thiebaud N, Gribble F, Reimann F, Trapp S, Fadool DA (2019). A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Sci Rep, 9(1):15542. PubMed
Huang Z, Hoffman CA, Chelette BM, Thiebaud N, Fadool DA (2018). Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice. Front Behav Neurosci, 12:49. PubMed
Bell GA, Fadool DA (2017). Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice. Physiol Behav, 104-113. PubMed
Huang Z, Thiebaud N, Fadool DA (2017). Differential serotonergic modulation across the main and accessory olfactory bulbs. J Physiol, 595(11):3515-3533. PubMed
Julliard AK, Al Koborssy D, Fadool DA, Palouzier-Paulignan B (2017). Nutrient sensing: Another chemosensitivity of the olfactory system. Front Physiol, 468. PubMed
Thiebaud N, Johnson MC, Butler JL, Bell GA, Ferguson KL, Fadool AR, Fadool JC, Gale AM, Gale DS, Fadool DA. (2014). Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning.. J Neurosci, 34(20):6970-84. PubMed