Accepting new graduate students.
Dr. Choogon Lee
Associate Professor of Biomedical Sciences & Neuroscience
- Circadian biology and metabolism.
- Current Research
- Our circadian clock is our body’s way of telling time, and it drives daily oscillations across our physiology and behavior: not only when we sleep and wake, but also our metabolism, digestive function, cardiac function, cognitive and emotional state, and tissue repair. We use mutant and transgenic mouse models along with mathematical models to emulate human sleep and circadian disorders. Our second line of research in the lab is driven by the fact that serious metabolic diseases such as obesity and type 2 diabetes continue to become more and more prevalent in Western nations due to changes in our dietary habits and lifestyle. While others are trying to tackle this problem through social, psychological, and neurobiological (e.g., modulation of appetite) approaches, we are exploring the possibility of treating these diseases through modulation of cell-intrinsic metabolic pathways such as glycolysis.
- Recent Publications
Beesley S, Kim DW, D'Alessandro M, Jin Y, Lee K, Joo H, Young Y, Tomko RJ Jr, Faulkner J, Gamsby J, Kim JK, Lee C (2020). Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis. Proc Natl Acad Sci U S A, 117(45):28402-28411. PubMed Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, Brenner C, Peek CB, Bass (2020). NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. J.Mol Cell, 78(5):835-849. PubMed Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, Okamura H (2019). Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity. Nat Commun, 10(1):2563. PubMed Jin YH, Joo H, Lee K, Kim H, Didier R, Yang Y, Shin H, Lee C (2019). Streamlined procedure for gene knockouts using all-in-one adenoviral CRISPR-Cas9. Sci Rep, 9(1):277. PubMed Lee C (2019). CRY arrests Cop1 to regulate circadian rhythms in mammals. Cell Div, 14:12. PubMed Rossetti ML, Esser KA, Lee C, Tomko RJ Jr, Eroshkin AM, Gordon BS (2019). Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion. Am J Physiol Endocrinol Metab, 317(4):E631-E645. PubMed Zhou T, Zheng Y, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W, Wang G, Ren Y (2019). Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci, 22(3):421-435. PubMed Ramanathan C, Kathale ND, Liu D, Lee C, Freeman DA, Hogenesch JB, Cao R, Liu AC (2018). mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet, 14(5):e1007369. PubMed D'Alessandro M, Beesley S, Kim JK, Jones Z, Chen R, Wi J, Kyle K, Vera D, Pagano M, Nowakowski R, Lee C (2017). Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein. Curr Biol, 27(22):3454-3467. PubMed Yoo SH, Kojima S, Shimomura K, Koike N, Buhr ED, Furukawa T, Ko CH, Gloston G, Ayoub C, Nohara K, Reyes BA, Tsuchiya Y, Yoo OJ, Yagita K, Lee C, Chen Z, Yamazaki S, Green CB, Takahashi JS (2017). Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation. Proc Natl Acad Sci U S A, 114(42):E8855-E8864. PubMed Kettner MN, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L (2016). Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis. Cancer Cell, 30(6):909-924. PubMed Matsu-Ura T, Dovzhenok A, Aihara E, Rood J, Le H, Ren Y, Rosselot AE, Zhang T, Lee C, Obrietan K, Montrose MH, Lim S, Moore SR, Hong CI (2016). Intercellular coupling of the cell cycle and circadian clock in adult stem cell culture. Mol Cell, 64(5):900-912. PubMed Pramudya I, Rico CG, Lee C, Chung H (2016). POSS-Containing bioinspired adhesives with enhanced mechanical and optical properties for biomedical applications. Biomacromolecules, 17(12):3853-3861. PubMed