Dr. Choogon Lee is currently accepting new graduate students.
Dr. Choogon Lee
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 2300L
- Circadian biology and metabolism.
- Current Research
- Our circadian clock is our body’s way of telling time, and it drives daily oscillations across our physiology and behavior: not only when we sleep and wake, but also our metabolism, digestive function, cardiac function, cognitive and emotional state, and tissue repair. We use mutant and transgenic mouse models along with mathematical models to emulate human sleep and circadian disorders. Our second line of research in the lab is driven by the fact that serious metabolic diseases such as obesity and type 2 diabetes continue to become more and more prevalent in Western nations due to changes in our dietary habits and lifestyle. While others are trying to tackle this problem through social, psychological, and neurobiological (e.g., modulation of appetite) approaches, we are exploring the possibility of treating these diseases through modulation of cell-intrinsic metabolic pathways such as glycolysis.
- Recent Publications
Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, Okamura H (2019). Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity. Nat Commun, 10(1):2563. PubMed Yoo SH, Kojima S, Shimomura K, Koike N, Buhr ED, Furukawa T, Ko CH, Gloston G, Ayoub C, Nohara K, Reyes BA, Tsuchiya Y, Yoo OJ, Yagita K, Lee C, Chen Z, Yamazaki S, Green CB, Takahashi JS (2017). Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation. Proc Natl Acad Sci U S A, 114(42):E8855-E8864. PubMed Kettner MN, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L (2016). Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis. Cancer Cell, 30(6):909-924. PubMed Matsu-Ura T, Dovzhenok A, Aihara E, Rood J, Le H, Ren Y, Rosselot AE, Zhang T, Lee C, Obrietan K, Montrose MH, Lim S, Moore SR, Hong CI (2016). Intercellular coupling of the cell cycle and circadian clock in adult stem cell culture. Mol Cell, 64(5):900-912. PubMed Pramudya I, Rico CG, Lee C, Chung H (2016). POSS-Containing bioinspired adhesives with enhanced mechanical and optical properties for biomedical applications. Biomacromolecules, 17(12):3853-3861. PubMed Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N (2015). Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nat Neurosci, 18(6):855-62. PubMed D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C (2015). A tunable artificial circadian clock in clock-defective mice. Net Commun, 6:8587. PubMed Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L (2015). Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metab, 22(3):448-59. PubMed