Florida State University

Dr. Richard Bertram

Brennan Professor of Mathematics, Neuroscience, and Molecular Biophysics

LOV 109 and IMB 402


The mechanisms underlying pulsatile hormone secretion and patterned neural activity.
Current Research
Hormones are often secreted from endocrine cells in a pulsatile manner, and downstream targets respond optimally to pulsatile input, demonstrating a physiological significance of this pattern of secretion. One focus of the research done in my lab is the biophysical mechanisms underlying this pulsatility. Much of our work is on insulin-secreting beta cells that are located in pancreatic islets of Langerhans, and on cells of the pituitary gland that secrete hormones related to reproduction and stress. The other major focus of my lab is on mechanisms through which networks of neurons produce patterned behavior. In particular, we are examining the neural basis of birdsong production in the zebra finch, which serves as an excellent model system for learned patterned behavior. The techniques used in my lab are largely mathematical or computational, typically done in close collaboration with experimental labs.
Recent Publications
Adablah JE, Vinson R, Roper MG, Bertram R (2019). Synchronization of pancreatic islets by periodic or non-periodic muscarinic agonist pulse trains. PLoS One, 14(2):e0211832. PubMed
Aggarwal M, Cogan N, Bertram R (2019). Where to look and how to look: Combining global sensitivity analysis with fast/slow analysis to study multi-timescale oscillations. Math Biosci, 314:1-12. PubMed
Bertram R, Kehrenberg C, Seinige D, Krischek C (2019). Peracetic acid reduces Campylobacter spp. on turkey skin: Effects of a spray treatment on microbial load, sensory and meat quality during storage. PLoS One, 98(10):5064-507398(10):5064-5073. PubMed
Bertram R, Kehrenberg C, Seinige D, Krischek C (2019). Peracetic acid reduces Campylobacter spp. numbers and total viable counts on broiler breast muscle and drumstick skins during modified atmosphere package storage. Poult Sci, 98(10):5064-5073. PubMed
Gunaratnam G, Tuchscherr L, Elhawy MI, Bertram R, Eisenbeis J, Spengler C, Tschernig T, Löffler B, Somerville GA, Jacobs K, Herrmann M, Bischoff M (2019). ClpC affects the intracellular survival capacity of Staphylococcus aureus in non-professional phagocytic cells. Sci Rep, 9(1):16267. PubMed
Hubbeling D, Wong A, Bertram R (2019). Diversity is important. J R Soc Med, 112(3):88. PubMed
Ross MT, Flores D, Bertram R, Johnson F, Wu W, Hyson RL (2019). Experience-Dependent Intrinsic Plasticity During Auditory Learning. J Neurosci, 1206-1221. PubMed
Sentis A, Bertram R, Dardenne N, Ramon-Portugal F, Louit I, Le Trionnaire G, Simon JC, Magro A, Pujol B, Hemptinne JL, Danchin E (2019). Different phenotypic plastic responses to predators observed among aphid lineages specialized on different host plants. Sci Rep, 9(1):9017. PubMed
Shaughnessy DW, Hyson RL, Bertram R, Wu W, Johnson F (2019). Female zebra finches do not sing yet share neural pathways necessary for singing in males. J Comp Neurol, 527(4):843-855. PubMed
Vo T, Bertram R (2019). Why pacing frequency affects the production of early afterdepolarizations in cardiomyocytes: An explanation revealed by slow-fast analysis of a minimal model. Phys Rev E, 99(5-1). PubMed
Wong PL, Bertram R, Hubbeling D (2019). CORE study: different interpretation of the results. Br J Psychiatry, 215(2):503. PubMed
Bertram R, Satin LS, Sherman AS (2018). Closing in on the Mechanisms of Pulsatile Insulin Secretion. Diabetes, 67(3):351-359. PubMed
Carroll BJ, Bertram R, Hyson RL (2018). Intrinsic physiology of inhibitory neurons changes over auditory development. J Neurophysiol, 119(1):290-304. PubMed
Galvis D, Wu W, Hyson RL, Johnson F, Bertram R (2018). Interhemispheric dominance switching in a neural network model for birdsong. J Neurophysiol, 120(3):1186-1197. PubMed
Hubbeling D, Sapunov A, Bertram R (2018). Basic Sciences and Psychiatry. Acad Psychiatry, 42(3):424-425. PubMed
McKenna JP, Bertram R (2018). Fast-slow analysis of the Integrated Oscillator Model for pancreatic Beta-cells. J Theor Biol, 457:152-162. PubMed
Bertram R, Rubin JE (2017). Multi-timescale systems and fast-slow analysis. Mathematical Biosciences, 105-121. PubMed
Blanco W, Bertram R, Tabak J (2017). The Effects of GABAergic Polarity Changes on Episodic Neural Network Activity in Developing Neural Systems. Front Comput Neurosci, 11:88. PubMed
Elliot KC, Wu W, Bertram R, Hyson RL, Johnson F (2017). Orthogonal topography in the parallel input architecture of songbird HVC. J Comp Neurol, 525(9):2133-2151. PubMed
Galvis D, Wu W, Hyson RL, Johnson F, Bertram R (2017). A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production. J Neurophysiol, 118(2):677-692. PubMed
Hubbeling D, Zarroug M, Bertram R (2017). Effects of patient mindset raise a legal dilemma. BMJ, 1271. PubMed
Meiers M, Laux A, Eichinger D, Sexauer A, Marx P, Bertram R, Brückner R (2017). A tetracycline-inducible integrative expression system for Streptococcus pneumoniae. FEMS Microbiol Lett, 364(5). PubMed
Ross MT, Flores D, Bertram R, Johnson F, Hyson RL (2017). Neuronal Intrinsic Physiology Changes During Development of a Learned Behavior. eNeuro, 4(5). PubMed
Sapunov A, Hubbeling D, Bertram R (2017). Factors in evaluating in-patient group psychotherapy. Acta Psychiatr Scand, 136(4):434. PubMed
Schmitter S, Fieseler L, Klumpp J, Bertram R, Loessner MJ (2017). TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA. Mol Microbiology, 105(3):413-425. PubMed
Weingard D, Blanco W, Steinbock O, Bertram R (2017). Stabilization of collapsing scroll waves in systems with random heterogeneities. Chaos, 27(4):043108. PubMed
Xu T, Wu Y, Lin Z, Bertram R, Götz F, Zhang Y, Qu D (2017). Identification of Genes Controlled by the Essential YycFG Two-Component System Reveals a Role for Biofilm Modulation in Staphylococcus epidermidis. Front Microbiology, 724. PubMed
Yildirim V, Bertram R (2017). Calcium oscillation frequency-sensitive gene regulation and homeostatic compensation in pancreatic B-cells. Bull Math Biol, 79(6):1295-1324. PubMed
Yildirim V, Vadrevu S, Thompson B, Satin LS, Bertram R (2017). Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets. PLoS Comput Biol, 13(7). PubMed
Bertram R (2016). Bacterial physiology: Persisters run out of fuel. Nat Micobiol, 1:16060. PubMed
Bertram R, Kaakinen J, Bensch F, Helle L, Lantto E, Niemi P, Lundbom N (2016). Eye Movements of Radiologists Reflect Expertise in CT Study Interpretation: A Potential Tool to Measure Resident Development. Radiology, 281(3):805-815. PubMed
Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ (2016). Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs. Endocrinology, 157(8):3108-21. PubMed
Fletcher P, Bertram R, Tabak J (2016). From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability. J Comput Neurosci, 40(3):331-45. PubMed
McKenna JP, Dhumpa R, Mukhitov N, Roper MG, Bertram R (2016). Glucose oscillations can activate an endogenous oscillator in pancreatic islets. PLoS Computational Biology, 12(10). PubMed
McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R (2016). Ca(2+) Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity. Biophys J, 110(3):733-742. PubMed
Mechler L, Bonetti EJ, Reichert S, Flötenmeyer M, Schrenzel J, Bertram R, François P, Götz F (2016). Daptomycin Tolerance in the Staphylococcus aureus pitA6 Mutant Is Due to Upregulation of the dlt Operon. Antimicrob Agents Chemother, 60(5):2684-91. PubMed
Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS (2016). Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet beta-Cells. Biophys J, 110(3):691-699. PubMed
Prax M, Mechler L, Weidenmaier C, Bertram R (2016). Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters. PLoS One, . PubMed
Schuster CF, Bertram R (2016). Toxin-Antitoxin Systems of Staphylococcus aureus. Toxins (Basel), ;8(5):140. PubMed
Stathopoulos AM, Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Bertram R (2016). Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats. Endocrine, 53(2):585-94. PubMed
Stathopoulos AM, Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Bertram R (2016). Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats. Endocrine, 53(2):585-94. PubMed
Tagliavini A, Tabak J, Bertram R, Pedersen MG (2016). Is bursting more effective than spiking in evoking pituitary hormone secretion? A spatiotemporal simulation study of calcium and granule dynamics. Am J Physiol Endocrinol Metab, 310(7):E515-25. PubMed
Yi L, Bandak B, Wang X, Bertram R, Roper MG (2016). Dual detection system for simultaneous measurement of intracellular fluorescent markers and cellular secretion. Analytical Chemistry, 88(21):10368-10373. PubMed
Bertram R (2015). Mathematical modeling in neuroendocrinology. Compr Physiol, 5(2):911-27. PubMed
Gonzalez-Iglesias AE, Fletcher PA, Arias-Cristancho JA, Cristancho-Gordo R, Helena CV, Bertram R, Tabak J (2015). Direct stimulatory effects of oxytocin in female rat gonadotrophs and somatotrophs in vitro: comparison with lactotrophs. Endocrinology, 600-12. PubMed
Helena CV, Toporikova N, Kalil B, Stathopoulos AM, Pogrebna VV, Carolino RO, Anselmo-Franci JA, Bertram R (2015). KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats. Endocrinology, 156(2):600-12. PubMed
Peercy BE, Sherman AS, Bertram R (2015). Modeling of glucose-induced cAMP oscillations in pancreatic beta cells: cAMP rocks when metabolism rolls. Biophys J, 109(2):439-49. PubMed

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Angie Davenport, Graduate Student - Mathematics

Daniel Galvis, Graduate Student - Mathematics

Joshua Kimrey, Graduate Student - Mathematics

Yeuran Oh, Graduate Student - Mathematics

Ryan Vinson, Graduate Student - Mathematics

Return to List