Dr. Richard Bertram
Brennan Professor of Mathematics, Neuroscience, and Molecular Biophysics
 Faculty
 Mathematics
 LOV 109 and IMB 402
 6447195

bertram@neuro.fsu.edu
 Interest
 The mechanisms underlying pulsatile hormone secretion and patterned neural activity.
 Current Research
 Hormones are often secreted from endocrine cells in a pulsatile manner, and downstream targets respond optimally to pulsatile input, demonstrating a physiological significance of this pattern of secretion. One focus of the research done in my lab is the biophysical mechanisms underlying this pulsatility. Much of our work is on insulinsecreting beta cells that are located in pancreatic islets of Langerhans, and on cells of the pituitary gland that secrete hormones related to reproduction and stress. The other major focus of my lab is on mechanisms through which networks of neurons produce patterned behavior. In particular, we are examining the neural basis of birdsong production in the zebra finch, which serves as an excellent model system for learned patterned behavior. The techniques used in my lab are largely mathematical or computational, typically done in close collaboration with experimental labs.
 Recent Publications

Bertram R, Kehrenberg C, Seinige D, Krischek C, Peracetic acid reduces Campylobacter spp. numbers and total viable counts on broiler breast muscle and drumstick skins during modified atmosphere package storage, Poult Sci, 2019 PubMed Aggarwal M, Cogan N, Bertram R, Where to look and how to look: Combining global sensitivity analysis with fast/slow analysis to study multitimescale oscillations, Math Biosci, 2019 PubMed Vo T, Bertram R, Why pacing frequency affects the production of early afterdepolarizations in cardiomyocytes: An explanation revealed by slowfast analysis of a minimal model, Phys Rev E, 2019 PubMed Sentis A, Bertram R, Dardenne N, RamonPortugal F, Louit I, Le Trionnaire G, Simon JC, Magro A, Pujol B, Hemptinne JL, Danchin E, Different phenotypic plastic responses to predators observed among aphid lineages specialized on different host plants, Sci Rep, 2019 PubMed Wong PL, Bertram R, Hubbeling D, CORE study: different interpretation of the results, Br J Psychiatry, 2019 PubMed Bertram R, Kehrenberg C, Seinige D, Krischek C, Peracetic acid reduces Campylobacter spp. on turkey skin: Effects of a spray treatment on microbial load, sensory and meat quality during storage, PLoS One, 2019 PubMed Gunaratnam G, Tuchscherr L, Elhawy MI, Bertram R, Eisenbeis J, Spengler C, Tschernig T, Löffler B, Somerville GA, Jacobs K, Herrmann M, Bischoff M, ClpC affects the intracellular survival capacity of Staphylococcus aureus in nonprofessional phagocytic cells, Sci Rep, 2019 PubMed Shaughnessy DW, Hyson RL, Bertram R, Wu W, Johnson F, Female zebra finches do not sing yet share neural pathways necessary for singing in males, J Comp Neurol, 2019 PubMed Ross MT, Flores D, Bertram R, Johnson F, Wu W, Hyson RL, ExperienceDependent Intrinsic Plasticity During Auditory Learning, J Neurosci, 2019 PubMed Adablah JE, Vinson R, Roper MG, Bertram R, Synchronization of pancreatic islets by periodic or nonperiodic muscarinic agonist pulse trains, PLoS One, 2019 PubMed Hubbeling D, Wong A, Bertram R, Diversity is important, J R Soc Med, 2019 PubMed Hubbeling D, Sapunov A, Bertram R, Basic Sciences and Psychiatry, Acad Psychiatry, 2018 PubMed Carroll BJ, Bertram R, Hyson RL, Intrinsic physiology of inhibitory neurons changes over auditory development, J Neurophysiol, 2018 PubMed Bertram R, Satin LS, Sherman AS, Closing in on the Mechanisms of Pulsatile Insulin Secretion, Diabetes, 2018 PubMed Galvis D, Wu W, Hyson RL, Johnson F, Bertram R , Interhemispheric dominance switching in a neural network model for birdsong, J Neurophysiol, 2018 PubMed McKenna JP, Bertram R , Fastslow analysis of the Integrated Oscillator Model for pancreatic Betacells, J Theor Biol, 2018 PubMed Hubbeling D, Zarroug M, Bertram R, Effects of patient mindset raise a legal dilemma, BMJ, 2017 PubMed Meiers M, Laux A, Eichinger D, Sexauer A, Marx P, Bertram R, Brückner R , A tetracyclineinducible integrative expression system for Streptococcus pneumoniae, FEMS Microbiol Lett, 2017 PubMed Xu T, Wu Y, Lin Z, Bertram R, Götz F, Zhang Y, Qu D , Identification of Genes Controlled by the Essential YycFG TwoComponent System Reveals a Role for Biofilm Modulation in Staphylococcus epidermidis, Front Microbiology, 2017 PubMed Schmitter S, Fieseler L, Klumpp J, Bertram R, Loessner MJ , TetRdependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA, Mol Microbiology, 2017 PubMed Sapunov A, Hubbeling D, Bertram R , Factors in evaluating inpatient group psychotherapy, Acta Psychiatr Scand, 2017 PubMed Ross MT, Flores D, Bertram R, Johnson F, Hyson RL , Neuronal Intrinsic Physiology Changes During Development of a Learned Behavior, eNeuro, 2017 PubMed Blanco W, Bertram R, Tabak J, The Effects of GABAergic Polarity Changes on Episodic Neural Network Activity in Developing Neural Systems, Front Comput Neurosci, 2017 PubMed Bertram R, Rubin JE, Multitimescale systems and fastslow analysis, Mathematical Biosciences, 2017 PubMed Elliot KC, Wu W, Bertram R, Hyson RL, Johnson F, Orthogonal topography in the parallel input architecture of songbird HVC, J Comp Neurol, 2017 PubMed Galvis D, Wu W, Hyson RL, Johnson F, Bertram R, A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production, J Neurophysiol, 2017 PubMed Weingard D, Blanco W, Steinbock O, Bertram R, Stabilization of collapsing scroll waves in systems with random heterogeneities, Chaos, 2017 PubMed Yildirim V, Bertram R, Calcium oscillation frequencysensitive gene regulation and homeostatic compensation in pancreatic Bcells, Bull Math Biol, 2017 PubMed Yildirim V, Vadrevu S, Thompson B, Satin LS, Bertram R, Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets, PLoS Comput Biol, 2017 PubMed Mechler L, Bonetti EJ, Reichert S, Flötenmeyer M, Schrenzel J, Bertram R, François P, Götz F , Daptomycin Tolerance in the Staphylococcus aureus pitA6 Mutant Is Due to Upregulation of the dlt Operon, Antimicrob Agents Chemother, 2016 PubMed Prax M, Mechler L, Weidenmaier C, Bertram R , Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters, PLoS One, 2016 PubMed Schuster CF, Bertram R, ToxinAntitoxin Systems of Staphylococcus aureus, Toxins (Basel), 2016 PubMed Bertram R, Kaakinen J, Bensch F, Helle L, Lantto E, Niemi P, Lundbom N , Eye Movements of Radiologists Reflect Expertise in CT Study Interpretation: A Potential Tool to Measure Resident Development, Radiology, 2016 PubMed Bertram R , Bacterial physiology: Persisters run out of fuel, Nat Micobiol, 2016 PubMed Stathopoulos AM, Helena CV, CristanchoGordo R, GonzalezIglesias AE, Bertram R, Influence of dynorphin on estradiol and cervical stimulationinduced prolactin surges in ovariectomized rats, Endocrine, 2016 PubMed Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ, Glucocorticoids Inhibit CRH/AVPEvoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs, Endocrinology, 2016 PubMed McKenna JP, Dhumpa R, Mukhitov N, Roper MG, Bertram R, Glucose oscillations can activate an endogenous oscillator in pancreatic islets, PLoS Computational Biology, 2016 PubMed Yi L, Bandak B, Wang X, Bertram R, Roper MG, Dual detection system for simultaneous measurement of intracellular fluorescent markers and cellular secretion, Analytical Chemistry, 2016 PubMed Tagliavini A, Tabak J, Bertram R, Pedersen MG, Is bursting more effective than spiking in evoking pituitary hormone secretion? A spatiotemporal simulation study of calcium and granule dynamics, Am J Physiol Endocrinol Metab, 2016 PubMed Stathopoulos AM, Helena CV, CristanchoGordo R, GonzalezIglesias AE, Bertram R, Influence of dynorphin on estradiol and cervical stimulationinduced prolactin surges in ovariectomized rats, Endocrine, 2016 PubMed Fletcher P, Bertram R, Tabak J, From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability, J Comput Neurosci, 2016 PubMed McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R, Ca(2+) Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity, Biophys J, 2016 PubMed Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS, Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet betaCells, Biophys J, 2016 PubMed GonzalezIglesias AE, Fletcher PA, AriasCristancho JA, CristanchoGordo R, Helena CV, Bertram R, Tabak J, Direct stimulatory effects of oxytocin in female rat gonadotrophs and somatotrophs in vitro: comparison with lactotrophs, Endocrinology, 2015 PubMed Peercy BE, Sherman AS, Bertram R, Modeling of glucoseinduced cAMP oscillations in pancreatic beta cells: cAMP rocks when metabolism rolls, Biophys J, 2015 PubMed Bertram R, Mathematical modeling in neuroendocrinology, Compr Physiol, 2015 PubMed Helena CV, Toporikova N, Kalil B, Stathopoulos AM, Pogrebna VV, Carolino RO, AnselmoFranci JA, Bertram R, KNDy Neurons Modulate the Magnitude of the SteroidInduced Luteinizing Hormone Surges in Ovariectomized Rats, Endocrinology, 2015 PubMed
All Publications
Lab Website
Neuro Grads and Postdocs
Angie Davenport, Graduate Student  Mathematics 
Daniel Galvis, Graduate Student  Mathematics 
Joshua Kimrey, Graduate Student  Mathematics 
Yeuran Oh, Graduate Student  Mathematics 
Ryan Vinson, Graduate Student  Mathematics 