Michelle Arbeitman
Interest
The Arbeitman lab studies the molecular-genetic specification of behaviors, with a focus on reproductive behaviors in fruit flies and mice. The goal is to understand how genes specify the potential for behavior in these well-studied model systems that allow for rapid progress as models for human disease analyses. The lab uses genomic, molecular-genetic, biochemical, developmental and computational approaches to address the genetic specification of behavior.
Current Research
Understanding how complex behaviors are specified at a molecular-genetic level is a major unsolved question in biology, for which we have very little understanding in any organism. The lab focuses on unlocking the molecular mechanisms used to specify sexual dimorphism in the nervous system that underlies differences in male and female reproductive behaviors using fruit flies and mice as a model.
Newell NR, Ray S, Dalton JE, Fortier JC, Kao JY, Chang PL, Nuzhdin SV, Arbeitman MN (2020). The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions. G3 (Bethesda), 10(3):967-983. PubMed
Andrew DJ, Chen EH, Manoli DS, Ryner LC, Arbeitman MN (2019). Sex and the Single Fly: A Perspective on the Career of Bruce S. Baker. Genetics, 4(6):979-81. PubMed
Arbeitman MN (2019). Maternal Experience Leads to Lasting Gene Expression Changes in Some Regions of the Mouse Brain.. G3 (Bethesda), 9(8):2623-2628. PubMed
Mathies LD, Ray S, Lopez-Alvillar K, Arbeitman MN, Davies AG, Bettinger JC (2019). mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister. BMC Genomics, 20(1):427. PubMed
Rice GR, Barmina O, Luecke D, Hu K, Arbeitman M, Kopp A (2019). Modular tissue-specific regulation of doublesex underpins sexually dimorphic development in Drosophila. Development, 6(7):1799-808. PubMed
Graze RM, Tzeng RY, Howard TS, Arbeitman MN (2018). Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila. BMC Genomics, 19(1):893. PubMed
Arbeitman MN, New FN, Fear JM, Howard TS, Dalton JE, Graze RM (2016). Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex. G3 (Bethesda), 1799-808. PubMed
Arbeitman MN, Newell NR (2016). Courtship Love Songs: doublesex Makes the Connection. Dev Cell, 37(6):486-8. PubMed
Newell NR, New FN, Dalton JE, McIntyre LM, Arbeitman MN (2016). Neurons That Underlie Drosophila melanogaster Reproductive Behaviors: Detection of a Large Male-Bias in Gene Expression in fruitless-Expressing Neurons. G3 (Bethesda), 6(8):2455-65. PubMed
Signor SA, Arbeitman MN, Nuzhdin SV (2016). Gene networks and developmental context: the importance of understanding complex gene expression patterns in evolution. Evol Dev, 18(3):201-9. PubMed
Vied C, Ray S, Badger CD, Bundy JL, Arbeitman MN, Nowakowski RS (2016). Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests basis for sex-specific susceptibility and severity of neurological disorders. J Comp Neurol, 524(13):2696-710. PubMed
Fear JM, Arbeitman MN, Salomon MP, Dalton JE, Tower J, Nuzhdin SV, McIntyre LM (2015). The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster. BMC Syst Biol, 9:53. PubMed
Ray S, Tzeng RY, DiCarlo LM, Bundy JL, Vied C, Tyson G, Nowakowski R, Arbeitman MN (2015). An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period. G3 (Bethesda), 6(1):221-33. PubMed