Dr Devon Graham
Research Assistant Professor
- I am a recently appointed research faculty member that has spent the majority of my career thus far examining the effects of perturbations to both the adult and the developing nervous systems at the molecular (mechanistic) and behavioral (functional) levels. During my postdoctoral fellowships, I utilized genetic (e.g., dopamine receptor disruption) and pharmacological (e.g., drugs of abuse, stress, environmental contaminants) manipulations to determine how these developmental disruptions alter homeostasis and contribute to the onset of neuropsychiatric disorders later in life. While I still am involved in these studies, I more recently have focused on the role of the glucagon-like peptide-1 receptor (GLP-1R) on drug reward and mood disorders. Specifically, my research focuses on understanding how subsets of GLP-1Rs within particular brain regions (e.g., the dentate gyrus of the hippocampus) contribute to the development of such diseases.
- Recent Publications
Amos-Kroohs RM, Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Vorhees CV, Williams MT (2016). Developmental stress and lead (Pb): Effects of maternal separation and/or Pb on corticosterone, monoamines, and blood Pb in rats. Neurotoxicology, . PubMed Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A (2016). Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Transl Psychiatry, . PubMed Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA (2015). Evidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry, . PubMed Graham DL, Buendia MA, Chapman MA, Durai HH, Stanwood GD (2015). Deletion of G-alpha-q in the telencephalon alters specific neurobehavioral outcomes. Synapse, . PubMed Sørensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A, Fink-Jensen A (2015). The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. Physiol Behav, . PubMed