Florida State University

Alina Stimmell

Graduate Student
PDB C350


Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting over 35 million people in the world and is the leading cause of dementia. One of the main issues with AD is that diagnosis occurs long after neurological damage has occurred from amyloid beta and tau pathologies. Being able to understand AD as early as possible, as soon as symptoms begin to appear, is crucial for gaining a better understanding of AD as well as developing any potential treatments. One of the earliest symptoms to arise in AD is getting lost in an environment. My research has focused primarily on the effects of early AD on spatial navigation, primarily with the ability to use landmarks to get oriented. I use a transgenic mouse model of AD to study the behavioral impacts of AD on spatial navigation, as well as look into a potential role of pathology (amyloid beta and tau) in the brains of these mice that may be leading to the behavioral impacts/impairments. Furthermore, I am interested in studying sleep as a potential recovery mechanism of cognitive function with spatial navigation, since sleep has been shown to be affected in AD leading to an increase in forms of tau common in AD as well as a decrease in the clearance of tau and amyloid beta in the brain (Lucey 2020).
Recent Publications
Cone, A. S., Yuan, X., Sun, L., Duke, L., Vreones, M. P., Carrier, A. N., Kenyon, S. M., Carver, S. R., Benthem, S. D., Stimmell, A. C., Moseley, S. C., Hike, D., Grant, S. C., Wilber, A. A., Olcese, J. M., Meckes, D. G. (2021). Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer’s disease-like phenotypes in a preclinical mouse model. Theranostics, doi: 10.7150/thno.62069.
Stimmell, A. C., Xu, Z., Moseley, S. C., Benthem, S. D., Fernandez, D. M., Dang, J. V., Santos-Molina, L. F., Anzalone, R. A., Garcia-Barbon, C. L., Rodriguez, S., Dixon, J. R., Wu, W., Wilber, A. A. (2021). Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse. Frontiers in Aging, doi: https://doi.org/10.3389/fragi.2021.655015.
Benthem, S. D., Skelin, I., Moseley, S. C., Stimmell, A. C., Dixon, J. R., Melilli, A. S., Molina, L., McNaughton, B. L., Wilber, A. A. (2020). Impaired Hippocampal-Cortical Interactions During Sleep in a Mouse Model of Alzheimer’s Disease. Current Biology, doi: https://doi.org/10.1016/j.cub.2020.04.087.
Stimmell, A. C., Baglietto-Vargas, D., Moseley, S. C., Lapointe, V., Thompson, L. M., LaFerla, F. M., McNaughton, B. L., Wilber, A. A. (2019). Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease.. Scientific Reports, doi: https://doi.org/10.1038/s41598-018-37151-z.

Faculty Advisor

Aaron Wilber, Psychology

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