Dr. Diana Williams is currently accepting new graduate students.
Dr. Diana Williams
Associate Professor of Psychology & Neuroscience
- PDB B330
- Obesity, diabetes and related metabolic disorders; overeating and binge eating; neural and endocrine control of food intake and body weight; communication between gut and brain; physiological and behavioral responses to overfeeding, palatable foods, dieting and starvation.
- Current Research
- What causes the feelings of hunger and fullness? What makes you decide to stop eating at the end of a meal? Why do so many of us overeat junk food? Why do some people seem naturally thin while others are prone to weight gain and obesity? My laboratory uses rodent models to investigate the diverse factors that control food intake and body weight. Currently, we are focused on how the gut communicates with the brain about nutrients coming into the gastrointestinal tract during meals, and how the brain integrates this information with food palatability, motivation, cues in the environment and learned habits that can promote eating even in the absence of metabolic need.
- Recent Publications
Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S (2019). Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes, 68(1):21-33. PubMed Keel PK, Bodell LP, Forney KJ, Appelbaum J, Williams DL (2019). Examining weight suppression as a transdiagnostic factor influencing illness trajectory in bulimic eating disorders. Physiol Behav, 208:112565. PubMed Terrill SJ, Holt MK, Maske CB, Abrams N, Reimann F, Trapp S, Williams DL (2019). Endogenous GLP-1 in lateral septum promotes satiety and suppresses motivation for food in mice. Physiol Behav, 191-199. PubMed Maske CB, Loney GC, Lilly N, Terrill SJ, Williams DL (2018). Intragastric nutrient infusion reduces motivation for food in male and female rats. Am J Physiol Endocrinol Metab, 315(1):E81-E90. PubMed Terrill SJ, Maske CB, Williams DL (2018). Endogenous GLP-1 in lateral septum contributes to stress-induced hypophagia. Physiol Behav, 17-22. PubMed Terrill SJ, Wall KD, Medina ND, Maske CB, Williams DL (2018). Lateral septum growth hormone secretagogue receptor affects food intake and motivation for sucrose reinforcement. Am J Physiol Regul Integr Comp Physiol, 315(1):R76-R83. PubMed Williams DL, Lilly NA, Edwards IJ, Yao P, Richards JE, Trapp S (2018). GLP-1 action in the mouse bed nucleus of the stria terminalis. Neuropharmacology, 83-95. PubMed Keel PK, Bodell LP, Haedt-Matt AA, Williams DL, Appelbaum J (2017). Weight suppression and bulimic syndrome maintenance: Preliminary findings for the mediating role of leptin. Int J Eat Disord, 50(12):1432-1436. PubMed Maske CB, Jackson CM, Terrill SJ, Eckel LA, Williams DL (2017). Estradiol modulates the anorexic response to central glucagon-like peptide 1. Horm Behav, 93:109-117. PubMed Terrill SJ, Hyde KM, Kay KE, Greene HE, Maske CB, Knierim AE, Davis JF, Williams DL (2016). Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback. Am J Physiol Regul Integr Comp Physio, 311(3):R592-9. PubMed Terrill SJ, Jackson CM, Greene HE, Lilly N, Maske CB, Vallejo S, Williams DL (2016). Role of lateral septum glucagon-like peptide 1 receptors in food intake. Am J Physiol Regul Integr Comp Physiol, 311(1):R124-32. PubMed Dossat AM, Bodell LP, Williams DL, Eckel LA, Keel PK (2015). Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa. Int J Eat Disord, 48(2):199-205. PubMed