Dr. Greg Hajcak
Professor of Biomedical Sciences, Psychology & Neuroscience
- PDB B439
- My work utilizes a range of psychophysiological and neurobiological measures (i.e., event-related brain potentials or ERPs, functional magnetic resonance imagining or fMRI, startle reflex, pupillometry, eye tracking, heart rate, and skin conductance) to understand cognition, emotion, and psychopathology. Some of my work is basic in nature – intending to clarify the measurement and key mechanisms of emotion-cognition interactions. As a clinical psychophysiologist, I leverage these neurobiological and psychophysiological measures to better understand individual differences in anxiety, depression, and psychosis in terms of abnormal affective-cognitive processes. Because neurobiological and psychophysiological measures are often understood in terms of ‘biomarkers’ of disease-related processes, I am increasingly examining the psychometric properties of these measures. The major thrust of my current research program is on prediction and modification: To what degree can neuroscience and psychophysiology predict changes in symptoms over time, and can neural measures of risk be modified?
- Current Research
- Our work focuses on the intersection between neuroscience and psychopathology – how the brain can be used to study individual differences. We're currently working on a range of projects--and many focus on neural measures of reward, as reflected in event-related brain potentials and functional magnetic resonance imaging. We are interested in how pubertal development and hormones impact reward sensitivity, especially in relation to individual differences in depression and depressive symptoms. Some of our projects examine whether neural response to reward can be altered by cognitive training and brain stimulation. We are also examining similar questions in terms of how the brain responds to emotional stimuli.
- Recent Publications
Albanese BJ, Hajcak G (2021). Reward processing abnormalities and promising new directions for understanding suicide vulnerability. Biol Psychiatry Cogn Neurosci Neuroimaging, 6(1):8-9. PubMed Brush CJ, Burani K, Schmidt KM, Santopetro NJ, Hajcak G (2021). The impact of a single session of aerobic exercise on positive emotional reactivity in depression: Insight into individual differences from the late positive potential. Behav Res Ther, 144:103914. PubMed Burani K, Gallyer A, Ryan J, Jordan C, Joiner T, Hajcak G (2021). Acute stress reduces reward-related neural activity: Evidence from the reward positivity. Stress, 1-7. PubMed Foell J, Klawohn J, Bruchnak A, Brush CJ, Patrick CJ, Hajcak G (2021). Ventral striatal activation during reward differs between major depression with and without impaired mood reactivity. Psychiatry Res Neuroimaging, 313:111298. PubMed Kappenman ES, Geddert R, Farrens JL, McDonald JJ, Hajcak G (2021). Recoiling from Threat: Anxiety is Related to Heightened Suppression of Threat, Not Increased Attention to Threat. Clin Psychol Sci, 9(3):434-448. PubMed Mulligan EM, Lowe M, Flynn H, Hajcak G (2021). The rewards of motherhood: Neural response to reward in pregnancy prospectively predicts maternal bonding with the infant in the postpartum period. Biol Psychol, 163:108148. PubMed Barch DM, Whalen D, Gilbert K, Kelly D, Kappenman ES, Hajcak G, Luby JL (2020). Neural indicators of anhedonia: Predictors and mechanisms of treatment change in a randomized clinical trial in early childhood depression. Biol Psychiatry, 88(11):879-887. PubMed Foti D, Perlman G, Bromet EJ, Harvey PD, Hajcak G, Mathalon DH, Kotov R. (2020). Pathways from performance monitoring to negative symptoms and functional outcomes in psychotic disorders. Psychol Med, 1-11. PubMed Klawohn J, Burani K, Bruchnak A, Santopetro N, & Hajcak, G (2020). Reduced Neural Response to Reward and Pleasant Pictures Independently Relate to Depression. Psychol Med, 51(5):741-749. PubMed Mulligan EM, Hajcak G, Crisler S, Meyer A (2020). Increased dehydroepiandrosterone (DHEA) is associated with anxiety in adolescent girls. Psychoneuroendocrinology, 119:104751. PubMed Mulligan EM, Infantolino ZP, Klein DN, Hajcak G (2020). Developmental trajectory of the late positive potential: Using temporal-spatial PCA to characterize withinsubject developmental changes in emotional processing. Psychophysiology, 57(2):e13478. PubMed Speed BC, Levinson AR, Gross JJ, Kiosses DN, Hajcak G (2020). Emotion regulation to idiographic stimuli: Testing the Autobiographical Emotion Regulation Task. Neuropsychologia, 145:106346. PubMed Burani K, Mulligan EM, Klawohn J, Luking KR, Nelson BD, Hajcak G (2019). Longitudinal increases in reward-related neural activity in early adolescence: Evidence from event-related potentials (ERPs). Dev Cogn Neurosci, 36:100620. PubMed Keifer CM, Hauschild KM, Nelson BD, Hajcak G, Lerner MD (2019). Differences in the Late Positive Potential and P300 to Emotional Faces in Individuals with Autism Spectrum Disorder. J Autism Dev Disord, 49(12):5009-5022. PubMed Lincoln SH, Pisoni A, Bondy E, Kumar P, Singleton P, Hajcak G, Pizzagalli DA, Auerbach RP (2019). Altered reward processing following an acute social stressor in adolescents. PLoS One, 14(1):e0209361. PubMed MacNamara A, Jackson TB, Fitzgerald JM, Hajcak G, Phan KL (2019). Working Memory Load and Negative Picture Processing: Neural and Behavioral Associations With Panic, Social Anxiety, and Positive Affect. Biol Psychiatry Cogn Neurosci Neuroimaging, 4(2):151-159. PubMed Peters AT, Burkhouse KL, Kujawa A, Afshar K, Fitzgerald KD, Monk CS, Hajcak G, Phan KL (2019). Impact of pubertal timing and depression on error-related brain activity in anxious youth. Dev Psychobiol, 61(1):69-80. PubMed Aase DM, Greenstein JE, Proescher E, Hajcak G, Phan KL (2018). Individual differences in combat experiences and error-related brain activity in OEF/OIF/OND veterans. Int J Psychophysiol, 52-57. PubMed Brush CJ, Ehmann PJ, Hajcak G, Selby EA, Alderman BL (2018). Using Multilevel Modeling to Examine Blunted Neural Responses to Reward in Major Depression. Biol Psychiatry Cogn Neurosci Neuroimaging, 3(12):1032-1039. PubMed Burkhouse KL, Gorka SM, Klumpp H, Kennedy AE, Karich S, Francis J, Ajilore O, Craske MG, Langenecker SA, Shankman SA, Hajcak G, Phan KL (2018). Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment. J Clin Psychiatry, 79(4):17m11836. PubMed Fitzgerald JM, Gorka SM, Kujawa A, DiGangi JA, Proescher E, Greenstein JE, Aase DM, Schroth C, Afshar K, Kennedy AE, Hajcak G, Phan KL (2018). Neural indices of emotional reactivity and regulation predict course of PTSD symptoms in combat-exposed veterans. Prog Neuropsychopharmacol Biol Psychiatry, 255-262. PubMed Howse AD, Hassall CD, Williams CC, Hajcak G, Krigolson OE (2018). Alcohol hangover impacts learning and reward processing within the medial-frontal cortex. Psychophysiology, 55(8):e13081. PubMed Kiosses DN, Alexopoulos GS, Hajcak G, Apfeldorf W, Duberstein PR, Putrino D, Gross JJ (2018). Cognitive Reappraisal Intervention for Suicide Prevention (CRISP) for Middle-Aged and Older Adults Hospitalized for Suicidality. Am J Geriatr Psychiatry, 26(4):494-503. PubMed Kujawa A, Carroll A, Mumper E, Mukherjee D, Kessel EM, Olino T, Hajcak G, Klein DN (2018). A longitudinal examination of event-related potentials sensitive to monetary reward and loss feedback from late childhood to middle adolescence. Int J Psychophysiol, 132(Pt B):323-330. PubMed Meyer A, Hajcak G, Torpey-Newman D, Kujawa A, Olino TM, Dyson M, Klein DN (2018). Early temperamental fearfulness and the developmental trajectory of error-related brain activity. Dev Psychobiol, 60(2):224-231. PubMed Mulligan EM, Hajcak G (2018). The electrocortical response to rewarding and aversive feedback: The reward positivity does not reflect salience in simple gambling tasks. Int J Psychophysiol, 262-267. PubMed Sachs-Ericsson NJ, Hajcak G, Sheffler JL, Stanley IH, Selby EA, Potter GG, Steffens DC (2018). Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age. J Geriatr Psychiatry Neurol, 31(1):39-49. PubMed Tsypes A, Owens M, Hajcak G, Gibb BE (2018). Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study. J Child Psychol Psychiatry, 59(12):1289-1297. PubMed Hajcak G, Meyer A, Kotov R (2017). Psychometrics and the neuroscience of individual differences: Internal consistency limits between-subjects effects. J Abnormal Psychol, 126(6):823-834. PubMed Masaki H, Maruo Y, Meyer A, Hajcak G (2017). Neural Correlates of Choking Under Pressure: Athletes High in Sports Anxiety Monitor Errors More When Performance Is Being Evaluated. Dev Neuropsychol, 42(2):104-112. PubMed Nelson BD, Jackson F, Amir N, Hajcak G (2017). Attention bias modification reduces neural correlates of response monitoring. Biol Psychol, 103-110. PubMed Speed BC, Jackson F, Nelson BD, Infantolino ZP, Hajcak G (2017). Unpredictability increases the error-related negativity in children and adolescents. Brain Cogn, 25-31. PubMed Waszczuk MA, Zimmerman M, Ruggero C, Li K, MacNamara A, Weinberg A, Hajcak G, Watson D, Kotov R (2017). What do clinicians treat: Diagnoses or symptoms? The incremental validity of a symptom-based, dimensional characterization of emotional disorders in predicting medication prescription patterns. Compr Psychiatry, 80-88. PubMed Nelson BD, Perlman G, Klein DN, Kotov R, Hajcak G (2016). Blunted neural response to rewards as a propective predictor of the development of depression in adolescent girls. Am J Psychiatry, 173(12):1223-1230. PubMed Speed BC, Nelson BD, Auerbach RP, Klein DN, Hajcak G (2016). Depression risk and electrocortical reactivity during self-referential emotional processing in 8 to 14 year-old girls. J Abnormal Psychol, 125(5):607-19. PubMed Weinberg A, Perlman G, Kotov R, Hajcak G (2016). Depression and reduced neural response to emotional images: Distinction from anxiety, and importance of symptom dimensions and age of onset. J Abnorm Psychol, 125(1):26-39. PubMed