Dr. Laura Blakemore
- Biological Science
- KIN 3011
- My research interests include understanding the mechanisms that influence neuronal excitability, synaptic transmission, and synaptic plasticity. These include mechanisms that underlie normal physiological events, such as those which mediate learning and memory, as well as mechanisms that contribute to neuropsychiatric disorders such as depression, anxiety, schizophrenia, and dementia.
- Current Research
- Our current research projects involve the use of primary neuronal culture, brain slices, and patch-clamp electrophysiology, in combination with molecular biology and histological techniques, to examine the expression and modulation of ligand-gated (ionotropic) receptors (e.g., glutamate, GABA, and glycine receptors) and G protein-coupled receptors (e.g., dopamine, NPY receptors). Projects also include investigating the role of zinc as a neuromodulator of neuronal circuit function.
- Recent Publications
Blakemore LJ, Trombley PQ (2019). Mechanisms of zinc modulation of olfactory bulb AMPA receptors. Neuroscience, . PubMed Blakemore LJ, Corthell J, Trombley PQ (2018). Kainate Receptors Play a Role in Modulating Synaptic Transmission in the Olfactory Bulb. Neuroscience, . PubMed Blakemore LJ, Trombley PQ (2017). Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb. Front Cell Neurosci, . PubMed Korshunov KS, Blakemore LJ, Trombley PQ (2017). Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System. Front Cell Neurosci, . PubMed Blakemore LJ, Tomat E, Lippard SJ, Trombley PQ (2013). Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve.. Metallomics, 5(3):208-13. PubMed Trombley PQ, Blakemore LJ, Hill BJ (2011). Zinc modulation of glycine receptors.. Neuroscience, 186:32-8. PubMed Blakemore LJ, Levenson CW, Trombley PQ (2006). Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb.. Neuroscience, 138(2):663-74. PubMed Blakemore LJ, Resasco M, Mercado MA, Trombley PQ (2006). Evidence for Ca(2+)-permeable AMPA receptors in the olfactory bulb.. Am J Physiol Cell Physiol, 290(3):C925-35. PubMed
Paul Trombley, Biological Science