Florida State University
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Amanda Dossat

Graduate Student
Biomedical Sciences
MSR 3310


Females have higher rates of depression as compared to males, with mood disorder symptoms often occurring during periods of ovarian hormone fluctuations. The NMDA receptor antagonist, Ketamine (KET), has shown promise as a rapid-acting antidepressant, exerting effects within hours of treatment. There is a growing wealth of data regarding the neural mechanisms that mediate this rapid antidepressant effect (e.g., BDNF and mTOR), yet sex differences in these molecular mechanisms remain to be resolved. My research aims to: 1) determine if C57BL/6 mice display sex differences in KET sensitivity, 2) determine the role of endogenous ovarian hormones and their respective receptors to promote KET sensitivity, & 3) examine whether the same molecular mechanisms mediating ketamine antidepressant effects described in male rodents also applies to females.
Recent Publications
Wright KN, Hollis F, Duclot F, Dossat AM, Strong CE, Francis TC, Mercer R, Feng J, Dietz DM, Lobo MK, Nestler EJ, Kabbaj M, Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner, J Neurosci, 2015 PubMed
Dossat AM, Bodell LP, Williams DL, Eckel LA, Keel PK, Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa, Int J Eat Disord, 2015 PubMed
Dossat AM, Diaz R, Gallo L, Panagos A, Kay K, Williams DL, Nucleus accumbens GLP-1 receptors influence meal size and palatability, Am J Physiol Endocrinol Metab, 2013 PubMed
Williams DL, Hyvarinen N, Lilly N, Kay K, Dossat A, Parise E, Torregrossa AM, Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation, Physiol Behav, 2011 PubMed
Dossat AM, Lilly N, Kay K, Williams DL, Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake, J Neurosci, 2011 PubMed
Parise EM, Lilly N, Kay K, Dossat AM, Seth R, Overton JM, Williams DL, Evidence for the role of hindbrain orexin-1 receptors in the control of meal size, Am J Physiol Regul Integr Comp Physiol, 2011 PubMed

Faculty Advisor

Mohamed Kabbaj, Biomedical Sciences

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