Dr. Yi Zhou
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 1350E
- Molecular and Neurobiological Basis of Mental Disorders; Functions and Regulation of Neuronal Ion Channels.
- Current Research
- A major focus of our research is to develop and characterize animal models for the study of human neuropsychiatric diseases. We have generated a line of transgenic mice that exhibit behavioral endophenotypes corresponding to the core symptoms of schizophrenia. Using a combination of electrophysiological, biochemical and imaging approaches, we also identified schizophrenia-related synaptic deficits in the brain of our mouse model. Currently, we are using this and other mouse models to investigate the neurobiology of schizophrenia at levels of molecules, synapses and neural circuits.
- Recent Publications
Bejoy J, Song L, Zhou Y, Li Y, Wnt/Yes-Associated protein interactions during neural tissue patterning of human induced pluripotent stem cells, Tissue Eng Part A, 2017 PubMed Wang Y, Wang YB, Sun H, Zhou A, Zhou Y & Li Y, Sequential Posttranslational Modifications Regulate PKC Degradation. , Molecular Biology of the Cell, 2016 PubMed Yan Y, Bejoy J, Xia J, Guan J, Zhou Y, Li Y, Neural patterning of human induced pluripotent stem cells in 3D cultures for studing biomolecule-directed differential cellular responses, Acta Biomater, 2016 PubMed Foote M, Qiao H, Graham K, Wu Y. & Zhou Y. , Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice., Biological Psychiatry, 2015 PubMed Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y & Li Y, 14-3-3tau promotes surface expression of Cav2.2 (alpha1B) Ca2+ channels, Journal of Biological Chemistry, 2015 PubMed Qiao H, Foote M, Graham K. Wu Y & Zhou, Y. , 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory, Journal of Neuroscience , 2014 PubMed Jia B, Wu Y & Zhou Y, 14-3-3 and aggresome formation: implications in neurodegenerative diseases, Prion , 2014 PubMed Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y & Li Y. , Modulation of Gluk2a-containing kainate receptors by 14-3-3 proteins, Journal of Biological Chemistry , 2013 PubMed Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y & Zhou Y, 14-3-3 targets chaperone-associated misfolded proteins to aggresomes, Journal of Cell Science , 2013 PubMed Zhou. Y., Zhao. M., Fields. G.G., Wu. C. & Branton. W.D. , Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca and Na channels, Plos One, 2013 PubMed Gao. X., Qiao. Y., Jia. B., Jing. X., Cheng. B., Wen. L., Tan,Q., Zhou. Z., Zhu. B., & Qiao, H. , NMDA Receptor-Dependent Synaptic Activity in DorsalMotor Nucleus of VagusMediates the Enhancement of GastricMotility by Stimulating ST36, Evidence-Based Complementary and Alternative Medicine, 2012 PubMed Foote, M & Zhou, Y. , 14-3-3 Proteins in Neurological Disorders, Int J Biochem Mol Biol, 2012 PubMed Huang, Z., Xu, Z., Wu, Y. & Zhou, Y, Determining nuclear localization of alpha-synuclein in mouse brains, Neuroscience, 2011 PubMed Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L.C. and Zhou, Y, Intracellular regions of the Eag channel play a critical role in generation of voltage-dependent currents, Journal of Biological Chemistry, 2011 PubMed Liu, X., Wu, Y., & Zhou, Y. , Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel, Channels, 2010 PubMed Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. , Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization, Journal of Biological Chemistry, 2009 PubMed Li ,Y., Wu, Y. and Zhou, Y. , Modulation of Inactivation Properties of Cav2.2 Channels by 14-3-3 Proteins, Neuron , 2006 PubMed