Dr. Yuan Wang
Assistant Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- We investigate the formation, dynamics, and pathology of the binaural circuit in the auditory brainstem. This circuit encodes acoustic information essential for sound and speech recognition in noisy environments, a common target across neurological disorders. We focus on the roles of the fragile X mental retardation protein (FMRP), which is responsible for the fragile X syndrome.
- Current Research
- We have four current research lines: 1) FMRP functional characterization in neuronal and circuit development in chickens using genetic manipulations; 2) FMRP function in neuronal dynamics regulated by excitatory input from the ears in mice and chickens; 3) Development of a transgenic gerbil model of fragile X syndrome for behavior studies; 4) Anatomical and biochemical studies of postmortem human brain tissues from individuals with autism and other neurological disorders.
- Recent Publications
Weatherstone JH, Kopp-Scheinpflug C, Pilati N, Wang Y, Forsythe ID, Rubel EW, Tempel BL, Maintenance of neuronal size gradient in MNTB requires sound-evoked activity, J Neurophysiol, 2017 PubMed Wang Y, Zorio DAR, Karten HJ, Heterogeneous organization and connectivity of the chicken auditory thalamus (Gallus gallus), J Comp Neurol, 2017 PubMed Sakano H, Zorio DAR, Wang X, Ting YS, Noble WS, MarCoss MJ, Rubel EW, Wang Y, Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein, J Comp Neurol, 2017 PubMed Zorio DA, Jackson CM, Liu Y, Rubel EW, Wang Y, Cellular distribution of the fragile X mental retardation protein in the mouse brain., J Comp Neurol, 2016 PubMed Beebe K, Wang Y, Kulesza R, Distribution of fragile X mental retardation protein in the human auditory brainstem, Neuroscience, 2014 PubMed Wang Y, Sakano H, Beebe K, Brown MR, de Laat R, Bothwell M, Kulesza RJ Jr, Rubel EW, Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: a comparative study in the alligator, chicken, gerbil, and human, J Comp Neurol, 2014 PubMed McBride EG, Rubel EW, Wang Y, Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2, J Comp Neurol, 2013 PubMed Seidl AH, Sanchez JT, Schecterson L, Tabor KM, Wang Y, Kashima DT, Poynter G, Huss D, Fraser SE, Lansford R, Rubel EW, Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem, J Comp Neurol, 2013 PubMed Wang Y, Rubel EW, In vivo reversible regulation of dendritic patterning by afferent input in bipolar auditory neurons, J Neurosci, 2012 PubMed Sanchez JT, Wang Y, Rubel EW, Barria A, Development of glutamatergic synaptic transmission in binaural auditory neurons, J Neurophysiol, 2010 PubMed Wang Y, Brzozowska-Prechtl A, Karten HJ, Laminar and columnar auditory cortex in avian brain, Proc Natl Acad Sci U S A, 2010 PubMed Wang Y, Karten HJ, Three subdivisions of the auditory midbrain in chicks (Gallus gallus) identified by their afferent and commissural projections, J Comp Neurol, 2010 PubMed Wang Y, Cunningham DE, Tempel BL, Rubel EW, Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem, J Comp Neurol, 2009 PubMed Wang Y, Rubel EW, Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity, Neuroscience, 2008 PubMed Gruberg E, Dudkin E, Wang Y, Marín G, Salas C, Sentis E, Letelier J, Mpodozis J, Malpeli J, Cui H, Ma R, Northmore D, Udin S, Influencing and interpreting visual input: the role of a visual feedback system, J Neurosci, 2006 PubMed Wang Y, Luksch H, Brecha NC, Karten HJ, Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): a possible substrate for synchronizing tectal channels, J Comp Neurol, 2006 PubMed Wang Y, Major DE, Karten HJ, Morphology and connections of nucleus isthmi pars magnocellularis in chicks (Gallus gallus), J Comp Neurol, 2004 PubMed Gu Y, Wang Y, Zhang T, Wang SR, Stimulus size selectivity and receptive field organization of ectostriatal neurons in the pigeon, J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2002 PubMed Gu Y, Wang Y, Wang SR, Visual responses of neurons in the nucleus of the basal optic root to stationary stimuli in pigeons, J Neurosci Res, 2002 PubMed Wang Y, Gu Y, Wang SR, Directional responses of basal optic neurons are modulated by the nucleus lentiformis mesencephali in pigeons, Neurosci Lett, 2001 PubMed Gu Y, Wang Y, Wang SR, Directional modulation of visual responses of pretectal neurons by accessory optic neurons in pigeons, Neuroscience, 2001 PubMed Wang Y, Xiao J, Wang SR, Excitatory and inhibitory receptive fields of tectal cells are differentially modified by magnocellular and parvocellular divisions of the pigeon nucleus isthmi, J Comp Physiol A, 2000 PubMed Wang Y, Gu Y, Wang SR, Modulatory effects of the nucleus of the basal optic root on rotundal neurons in pigeons, Brain Behav Evol, 2000 PubMed Wang Y, Gu Y, Wang SR, Feature detection of visual neurons in the nucleus of the basal optic root in pigeons, Brain Res Bull, 2000 PubMed Gu Y, Wang Y, Wang S, Regional variation in receptive field properties of tectal neurons in pigeons, Brain Behav Evol, 2000 PubMed Xiao J, Wang Y, Wang SR, Effects of glutamatergic, cholinergic and gabaergic antagonists on tectal cells in toads, Neuroscience, 1999 PubMed