Dr. Yi Ren
Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- Dr. Yi Ren’s Lab is interested in the molecular cell biology of inflammation, especially macrophage function in CNS trauma and tumor progression.
- Current Research
- 1. To demonstrate the pathophysiological roles of myelin-laden macrophages in SCI and provide experimental support for novel therapeutic interventions. 2. To study the underlying biologic pathways associated with stem cell-induced macrophage activation. 3. To understand the molecular basis of autism spectrum disorders (ASD) based upon large-scale gene expression profiling and to explore whether inflammatory response, particularly macrophage activation, contributes to the pathogenesis of ASD.
- Recent Publications
Cheng Z, Bosco DB, Sun L, Chen X, Xu Y, Tai W, Didier R, Li J, Fan J, He X, Ren Y, Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery, Cell Transplant , 2017 PubMed Xia J, Wang Z, Yan Y, Cheng Z, Sun L, Li Y, Ren Y, Guan J, Catalese-laden microdevices for cell-mediated enzyme delivery , Langmuir, 2016 PubMed Sun X, Jones ZB, Chen XM, Zhou L, So KF, Ren Y, Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship, J Neuroinflammation , 2016 PubMed Cheng Z, Zhu W, Cao K, Wu F, Li J, Wang G, Li H, Lu M, Ren Y, He X, Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury, Int J Mol Sci, 2016 PubMed Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ, Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury, Cell Rep, 2016 PubMed Guo L, Rolfe Aj, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y, Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media, Mol Brain, 2016 PubMed Rolfe AJ, Bosco DB, Wang J, Nowakowski RS, Fan J, Ren Y, Bioinformatic analysis reveals the expression of unique transcriptomic signatures Zika virus infected human neural stem cells, Cell Biosci, 2016 PubMed Lai XH, Zhao LF, Chen XM, Ren Y, Rapid identification and characterization of francisella by molecular biology and other techniques, Open Microbiol J, 2016 PubMed Jones ZB, Ren Y, Sphingolipids in spinal cord injury, Int J Physiol Pathophysiol Pharmacol, 2016 PubMed Sun YB, Qu X, Howard V, Dai L, Jiang X, Ren Y, Fu P, Puelles VG, Nikolic-Paterson DJ, Caruana G, Bertram JF, Sleeman MW, Li J, Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance, Kidney Int, 2015 PubMed Wang X, Cao K, Sun X, Chen Y, Duan Z, Sun L, Guo L, Bai P, Sun D, Fan J, He X, Young W, Ren Y, Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris, Glia, 2015 PubMed Yao XM, Chen ZL, Shen DL, Zhou QS, Huang SS, Cai ZR, Tong YL, Wang M, Ren Y, Lai XH, Chen XM, Risk factors for pediatric intussusception complicated by loss of intestine viability in China from June 2009 to May 2014: a retrospective study, Pediatr Surg Int, 2015 PubMed Qu X, Jiang M, Sun YB, Jiang X, Fu P, Ren Y, Wang D, Dai L, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J, The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction, Kidney Int, 2015 PubMed Zhou X, He X, Ren Y, Function of microglia and macrophages in secondary damage after spinal cord injury, Neural Regen Res, 2014 PubMed Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J, Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane, PLoS One, 2014 PubMed Chen T, Wang X, Guo L, Wu M, Duan Z, Lv J, Tai W, Renganathan H, Didier R, Li J, Sun D, Chen X, He X, Fan J, Young W, Ren Y, Embryonic Stem Cells Promoting Macrophage Survival and Function are Crucial for Teratoma Development, Front Immunol, 2014 PubMed Qu X, Li X, Zheng Y, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson DJ, Li J, Regulation of renal fibrosis by Smad3 Thr388 phosphorylation, Am J Pathol, 2014 PubMed Ren Y, Young W, Managing inflammation after spinal cord injury through manipulation of macrophage function, Neural Plast, 2013 PubMed Zhang X, Chen L, Wang Y, Ding Y, Peng Z, Duan L, Ju G, Ren Y, Wang X, Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/beta-catenin signal pathway, Int J Biol Sci, 2013 PubMed Wang X, Chen T, Leng L, Fan J, Cao K, Duan Z, Zhang X, Shao C, Wu M, Tadmori I, Li T, Liang L, Sun D, Zheng S, Meinhardt A, Young W, Bucala R, Ren Y, MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation, Cancer Res, 2012 PubMed Ren Y, Peroxisome Proliferator-Activator Receptor Gamma: A Link between Macrophage CD36 and Inflammation in Malaria Infection, PPAR Res, 2012 PubMed Zhu Z, Kremer P, Tadmori I, Ren Y, Sun D, He X, Young W, Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta, PLoS One, 2011 PubMed Shi LM, et al., The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models, Nat Biotechnol, 2010 PubMed Sun X, Wang X, Chen T, Li T, Cao K, Lu A, Chen Y, Sun D, Luo J, Fan J, Young W, Ren Y, Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system, PLoS One, 2010 PubMed