Dr. Diana Williams
Associate Professor of Psychology & Neuroscience
- PDB B330
- Obesity, diabetes and related metabolic disorders; overeating and binge eating; neural and endocrine control of food intake and body weight; communication between gut and brain; physiological and behavioral responses to overfeeding, palatable foods, dieting and starvation.
- Current Research
- What causes the feelings of hunger and fullness? What makes you decide to stop eating at the end of a meal? Why do so many of us overeat junk food? Why do some people seem naturally thin while others are prone to weight gain and obesity? My laboratory uses rodent models to investigate the diverse factors that control food intake and body weight. Currently, we are focused on how the gut communicates with the brain about nutrients coming into the gastrointestinal tract during meals, and how the brain integrates this information with food palatability, motivation, cues in the environment and learned habits that can promote eating even in the absence of metabolic need.
- Recent Publications
Maske CB, Jackson CM, Terrill SJ, Eckel LA, Williams DL, Estradiol modulates the anorexic response to central glucagon-like peptide 1, Horm Behav, 2017 PubMed Terrill SJ, Hyde KM, Kay KE, Greene HE, Maske CB, Knierim AE, Davis JF, Williams DL, Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback., Am J Physiol Regul Integr Comp Physio, 2016 PubMed Terrill SJ, Jackson CM, Greene HE, Lilly N, Maske CB, Vallejo S, Williams DL, Role of lateral septum glucagon-like peptide 1 receptors in food intake., Am J Physiol Regul Integr Comp Physiol, 2016 PubMed Williams DL, Neural integration of satiation and food reward: role of GLP-1 and orexin pathways, Physiol Behav, 2014 PubMed Kay K, Parise EM, Lilly N, Williams DL, Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats, Psychopharmacology (Berl), 2014 PubMed Mullis K, Kay K, Williams DL, Oxytocin action in the ventral tegmental area affects sucrose intake, Brain Res, 2013 PubMed Dossat AM, Diaz R, Gallo L, Panagos A, Kay K, Williams DL, Nucleus accumbens GLP-1 receptors influence meal size and palatability, Am J Physiol Endocrinol Metab, 2013 PubMed Williams DL, Hyvarinen N, Lilly N, Kay K, Dossat A, Parise E, Torregrossa AM, Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation, Physiol Behav, 2011 PubMed Dossat AM, Lilly N, Kay K, Williams DL, Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake, J Neurosci, 2011 PubMed Parise EM, Lilly N, Kay K, Dossat AM, Seth R, Overton JM, Williams DL, Evidence for the role of hindbrain orexin-1 receptors in the control of meal size, Am J Physiol Regul Integr Comp Physiol, 2011 PubMed Williams DL, Expecting to eat: glucagon-like peptide-1 and the anticipation of meals, Endocrinology, 2010 PubMed Williams DL, Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis, Endocrinology, 2009 PubMed Williams DL, Baskin DG, Schwartz MW, Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety, Endocrinology, 2009 PubMed Williams DL, Baskin DG, Schwartz MW, Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin, Am J Physiol Regul Integr Comp Physiol, 2009 PubMed Williams DL, Schwartz MW, Bastian LS, Blevins JE, Baskin DG, Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin, J Histochem Cytochem, 2008 PubMed