Dr. Paul Trombley
Associate Professor of Biology & Neuroscience
- Biological Science
- BRF 207
- The primary research goal of our laboratory is to understand the cellular and molecular mechanisms that regulate neuronal excitability and the efficacy of synaptic transmission. Our experimental approach uses primary neuronal culture, brain slices, and patch-clamp electrophysiology, in combination with molecular biology and histological techniques, to examine modulation of ion channels, neurotransmitter receptors, and synaptic circuits.
- Current Research
- One of our current projects involves determining the cellular and molecular basis of circadian rhythms in the olfactory system. We are exploring how electrical synapses formed by gap junctions and rhythmic expression of monoamine neurotransmitters (norepinephrine, dopamine, serotonin, and melatonin) contribute to rhythmic regulation of synaptic circuits underlying odor information processing. Other projects include investigating the role of zinc as a neuromodulator and the function of circuits of the hippocampus, hypothalamus, and amygdala.
- Recent Publications
Korshunov KS, Blakemore LJ, Trombley PQ, Dopamine: A modulator of circadian rhythms in the central nervous system, Front Cell Neurosci, 2017 PubMed Corthell JT, Olcese J, Trombley PQ, Melatonin in the mammalian olfactory bulb, Neuroscience, 2014 PubMed Corthell JT, Stathopoulos AM, Watson CC, Bertram R, Trombley PQ, Olfactory bulb monoamine concentrations vary with time of day, Neuroscience, 2013 PubMed Blakemore LJ, Tomat E, Lippard SJ, Trombley PQ, Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve, Metallomics, 2013 PubMed Corthell JT, Fadool DA, Trombley PQ, Connexin and AMPA receptor expression changes over time in the rat olfactory bulb, Neuroscience, 2012 PubMed Trombley PQ, Blakemore LJ, Hill BJ, Zinc modulation of glycine receptors, Neuroscience, 2011 PubMed Davila NG, Houpt TA, Trombley PQ, Expression and function of kainate receptors in the rat olfactory bulb, Synapse, 2007 PubMed Blakemore LJ, Levenson CW, Trombley PQ, Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb, Neuroscience, 2006 PubMed Blakemore LJ, Resasco M, Mercado MA, Trombley PQ, Evidence for Ca(2+)-permeable AMPA receptors in the olfactory bulb, Am J Physiol Regul Integr Comp Physiol, 2006 PubMed Horning MS, Kwon B, Blakemore LJ, Spencer CM, Goltz M, Houpt TA, Trombley PQ, Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunit expression in rat olfactory bulb, Neurosci Lett, 2004 PubMed Blakemore LJ, Trombley PQ, Diverse modulation of olfactory bulb AMPA receptors by zinc, Neuroreport, 2004 PubMed