Dr. Alan Spector
Distinguished Research Professor of Psychology & Neuroscience
- PDB B334
- Neural basis of gustation, animal psychophysics, sensory processes, regulation of ingestive behavior, taste preferences and aversions.
- Current Research
- Assessment of taste function in mice with genetic deletions of taste receptors • Analysis of alterations in taste function and ingestive behavior associated with gastric bypass surgery • Evaluation of taste function following targeted damage in central gustatory structures • Analysis of function following transection and regeneration of gustatory nerves.
- Recent Publications
Hyde KM, Blonde GD, le Roux CW, Spector AC, Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection, Physiol Behav, 2017 PubMed Schier LA, Blonde GD, Spector AC, Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats, J Comp Neurol, 2016 PubMed Schier LA, Spector AC, Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats., J Neurosci, 2016 PubMed Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC, Roux-en-Y Gastric Bypass in Rats Progressively Decreases the Proportion of Fat Calories Selected from a Palatable Cafeteria Diet., Am J Physiol Regul Integr Comp Physiol, 2016 PubMed Blonde GD, Bales MB, Spector AC, Extensive lesions in rat insular cortex significantly disrupt taste sensitivity to NaCl and KCl and slow salt discrimination learning, PLoS One, 2015 PubMed Spector AC, Blonde GD, Henderson RP, Treesukosol Y, Hendrick P, Newsome R, Fletcher FH, Tang T, Donaldson JA, A new gustometer for taste testing in rodents, Chem Senses, 2015 PubMed Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, Lutz TA, le Roux CW, Spector AC, Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat, Physiol Behav, 2015 PubMed Spector AC, Behavioral analyses of taste function and ingestion in rodent models., Physiol Behav, 2015 PubMed Smith KR, Spector AC, The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically, J Neurosci, 2014 PubMed King CT, Garcea M, Spector AC, Restoration of quinine-stimulated Fos-immunoreactive neurons in the central nucleus of the amygdala and gustatory cortex following reinnervation or cross-reinnervation of the lingual taste nerves in rats, J Comp Neurol, 2014 PubMed Schier LA, Hashimoto K, Bales MB, Blonde GD, Spector AC, High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning, Proc Natl Acad Sci U S A, 2014 PubMed Mathes CM, Bueter M, Smith KR, Lutz TA, le Roux CW, Spector AC, Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation, Am J Physiol Regul Integr Comp Physiol, 2012 PubMed Mathes CM, Spector AC, Food selection and taste changes in humans after Roux-en-Y gastric bypass surgery: a direct-measures approach, Physiol Behav, 2012 PubMed Loney GC, Blonde GD, Eckel LA, Spector AC, Determinants of taste preference and acceptability: quality versus hedonics, J Neurosci, 2012 PubMed Smith KR, Treesukosol Y, Paedae AB, Contreras RJ, Spector AC, Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses, Am J Physiol Regul Integr Comp Physiol, 2012 PubMed Treesukosol Y, Smith KR, Spector AC, The functional role of the T1R family of receptors in sweet taste and feeding, Physiol Behav, 2011 PubMed Treesukosol Y, Smith KR, Spector AC, Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model, J Neurosci, 2011 PubMed Blonde G, Jiang E, Garcea M, Spector AC, Learning-based recovery from perceptual impairment in salt discrimination after permanently altered peripheral gustatory input, Am J Physiol Regul Integr Comp Physiol, 2010 PubMed King CT, Garcea M, Stolzenberg DS, Spector AC, Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation, Am J Physiol Regul Integr Comp Physiol, 2008 PubMed Dotson CD, Spector AC, Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of T1R ligands, J Neurosci, 2007 PubMed Spector AC, Kopka SL, Rats fail to discriminate quinine from denatonium: implications for the neural coding of bitter-tasting compounds, J Neurosci, 2002 PubMed King CT, Garcea M, Spector AC, Glossopharyngeal nerve regeneration is essential for the complete recovery of quinine-stimulated oromotor rejection behaviors and central patterns of neuronal activity in the nucleus of the solitary tract in the rat, J Neurosci, 2000 PubMed