Dr. James Olcese
Professor of Biomedical Sciences, Neuroscience & Molecular Biophysics
- Biomedical Sciences
- MSR 2300E
- The Olcese lab investigates the role of cellular circadian clocks and hormonal outputs of the central circadian clock on neurological and physiological events, including sleep, cognitive performance (learning and memory), and the timing of human labor. In particular, we study the role of sleep and the brain hormone melatonin on cognitive changes that accompany aging, especially in the context of Alzheimer’s dementia. In addition, we are running clinical trials on the impact of blue light exposure on uterine contractions during late pregnancy with the goal of developing a novel medical device to reduce the risk of preterm labor.
- Current Research
- Our studies include experiments on the effects of melatonin on neuronal cells in culture as well as effects of melatonin on the development of Alzheimer-related neuropathology in transgenic mice at both the molecular and behavioral levels. Our studies in reproductive biology involve both molecular/cellular analyses of human myometrial smooth muscle cells in culture as well as trials with pregnant human volunteers.
- Recent Publications
O'Neal-Moffitt G, Delic V, Bradshaw PC, Olcese J, Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in APP(swe)/PS1 mice, Mol Neurodegener, 2015 PubMed Beesley S, Lee J, Olcese J, Circadian clock regulation of melatonin MTNR1B receptor expression in human myometrial smooth muscle cells, Mol Hum Reprod, 2015 PubMed Olcese J, Beesley S, Clinical significance of melatonin receptors in the human myometrium, Fertil Steril, 2014 PubMed O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J, Genetic deletion of MT?/MT? melatonin receptors enhances murine cognitive and motor performance, Neuroscience, 2014 PubMed Nair-Collins M, Northrup J, Olcese J, Hypothalamic-Pituitary Function in Brain Death: A Review, J Intensive Care Med, 2014 PubMed Corthell JT, Olcese J, Trombley PQ, Melatonin in the mammalian olfactory bulb, Neuroscience, 2014 PubMed Olcese J, Lozier S, Paradise C, Melatonin and the circadian timing of human parturition, Reprod Sci, 2012 PubMed Dragicevic N, Copes N, O’Neal-Moffitt G, Jin J, Buzzeo R, Mamcarz M, Tan J, Cao C, Olcese JM, Arendash GW, Bradshaw PC, Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling, J Pineal Res, 2011 PubMed Sharkey J, Cable C, Olcese J, Melatonin sensitizes human myometrial cells to oxytocin in a protein kinase C alpha/extracellular-signal regulated kinase-dependent manner, J Clin Endocrinol Metab, 2010 PubMed Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J, International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors, Pharmacol Rev, 2010 PubMed Sharkey JT, Puttaramu R, Word RA, Olcese J, Melatonin synergizes with oxytocin to enhance contractility of human myometrial smooth muscle cells, J Clin Endocrinol Metab, 2009 PubMed Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW, Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease, J Pineal Res, 2009 PubMed Resuehr HE, Resuehr D, Olcese J, Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1, Mol Cell Endocrinol, 2009 PubMed Sharkey J, Olcese J, Transcriptional inhibition of oxytocin receptor expression in human myometrial cells by melatonin involves protein kinase C signaling, J Clin Endocrinol Metab, 2007 PubMed Resuehr D, Wildemann U, Sikes H, Olcese J, E-box regulation of gonadotropin-releasing hormone (GnRH) receptor expression in immortalized gonadotrope cells, Mol Cell Endocrinol, 2007 PubMed Resuehr D, Sikes HE, Olcese J, Exploratory investigation of the effect of melatonin and caloric restriction on the temporal expression of murine hypothalamic transcripts, J Neuroendocrinol, 2006 PubMed Olcese J, Sikes HE, Resuehr D, Induction of PER1 mRNA expression in immortalized gonadotropes by gonadotropin-releasing hormone (GnRH): involvement of protein kinase C and MAP kinase signaling, Chronobiol Int, 2006 PubMed Resuehr D, Olcese J, Caloric restriction and melatonin substitution: effects on murine circadian parameters, Brain Res, 2005 PubMed