Dr. Derek Nee
Assistant Professor of Psychology & Neuroscience
- PDB B433
- Our lab examines how behavior is guided by internal representations to perform goal-directed action. This requires understanding cognitive control, which promotes goal-relevant processing over habitual tendencies, and working memory, which sustains and transforms information that is no longer available to the senses. We study humans using functional MRI (fMRI), transcranial magnetic stimulation (TMS), experimental psychology, and combinations thereof.
- Current Research
- In the domain of cognitive control, our current focus is on detailing the dynamic interactions among areas of the prefrontal cortex and sub-cortex that support goal-directed cognition. Using fMRI, we construct models of directed regional influences during situations requiring cognitive control. These models are then tested using TMS to observe predicted consequences of neural perturbation on brain networks and behavior. In the domain of working memory, we are presently examining the neural mechanisms underlying prioritizing information in mind (e.g. focusing on one thing vs. holding something thing in mind for later). This involves fitting models of neural representation to multi-variate fMRI data. We are also interested in how the medial temporal lobe and prefrontal cortex promote binding of short-term information to support the construction of novel associations for higher-level cognition.
- Recent Publications
Nee DE, D'Esposito M, Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control, Elife, 2017 PubMed Nee DE, D'Esposito M, The hierarchical organization of the lateral prefrontal cortex, Elife, 2016 PubMed Rahnev D, Nee DE, Riddle J, Larson AS, D'Esposito M, Causal evidence for frontal cortex organization for perceptual decision making, Proc Natl Acad Sci U S A, 2016 PubMed Nee DE, Jonides J, Frontal-medial temporal interactions mediate transitions among representational states in short-term memory, J Neurosci, 2014 PubMed Eich TS, Nee DE, Insel C, Malapani C, Smith EE, , Biol Psychiatry, 2014 PubMed Nee DE, Jahn A, Brown JW, Prefrontal cortex organization: dissociating effects of temporal abstraction, relational abstraction, and integration with FMRI, Cereb Cortex, 2014 PubMed Nee DE, Brown JW, Askren MK, Berman MG, Demiralp E, Krawitz A, Jonides J , A meta-analysis of executive components of working memory, Cereb Cortex, 2013 PubMed Nee DE, Jonides J, Neural evidence for a 3-state model of visual short-term memory, Neuroimage, 2013 PubMed Nee DE, Brown JW, Dissociable frontal-striatal and frontal-parietal networks involved in updating hierarchical contexts in working memory, Cereb Cortex, 2013 PubMed Nee DE, Jonides J, Trisecting representational states in short-term memory, Front Hum Neurosci, 2013 PubMed Nee DE, Brown JW, Rostral-caudal gradients of abstraction revealed by multi-variate pattern analysis of working memory, Neuroimage, 2012 PubMed Nee DE, Jonides J, Dissociable contributions of prefrontal cortex and the hippocampus to short-term memory: evidence for a 3-state model of memory, Neuroimage, 2011 PubMed Joormann J, Nee DE, Berman MG, Jonides J, Gotlib IH, Interference resolution in major depression, Cogn Affect Behav Neurosci, 2010 PubMed Nee DE, Jonides J, Neural correlates of access to short-term memory, Proc Natl Acad Sci U S A, 2008 PubMed