Florida State University

Dr. Linda Rinaman is currently accepting new students.

Lrinaman 5957f68b23c597bebf02675926a9e267f2f5d220f2cfbc13f454453e5244b7ec

Dr. Linda Rinaman

Professor of Psychology and Neuroscience

Faculty
Psychology
PDB B434
645-7128

rinaman@psy.fsu.edu

Interest
The ability of animals to mount adaptive responses to emotional and physiological stress is mediated by central neural pathways that control neuroendocrine secretion, autonomic function, and motivated behavior. The long-term objective of Dr. Rinaman's research program is to characterize the functional multisynaptic organization of these neural systems. Neuroanatomical, physiological, and behavioral techniques are applied to probe these circuits in rodent species under different metabolic and dietary conditions (e.g., after an overnight fast, or after maintenance on a high-fat diet) that markedly shift homeostatic responses to stress. This research program offers unique opportunities to test hypotheses about brain structure-function relationships.
Current Research
Current projects include a focus on central noradrenergic, glucagon-like peptide 1 (GLP1), and oxytocin-expressing neural signaling pathways. Ongoing studies in the laboratory analyze stimulus-induced expression of the immediate-early protooncogene c-fos (a marker of neural activation) in rats after exposure to various stress- and anxiety-provoking challenges. Analysis of c-fos expression is combined with retrograde labeling of central neural pathways and immunocytochemical detection of neurotransmitter chemicals to characterize the axonal projections and chemical phenotypes of stimulus-activated cells. These experiments focus on the functional roles played by central noradrenergic and peptidergic neural circuits that link brainstem regions with the hypothalamus and limbic forebrain. Another ongoing project uses live neurotropic viruses for transneuronal tracing of multisynaptic neural circuits that regulate food intake. Other experiments measure changes in hormone secretion and behavior to assess the impact of various physiological and pharmacological stimuli on centrally-mediated stress and anxiety responses.
Recent Publications
Zheng H, Rinaman L, Simplified CLARITY for visualizing immunofluorescence labeling in the developing rat brain., Brain Struct Funct, 2016 PubMed
Kojima S, Catavero C, Rinaman L., Maternal high-fat diet increases independent feeding in pre-weanling rat pups., Physiol Behav., 2016 PubMed
Kreisler AD, Rinaman L., Hindbrain glucagon-like peptide-1 neurons track intake volume and contribute to injection stress-induced hypophagia in meal-entrained rats., Am J Physiol Regul Integr Comp Physiol., 2016 PubMed
Zheng H, Stornetta RL, Agassandian K, Rinaman L., Glutamatergic phenotype of glucagon-like peptide 1 neurons in the caudal nucleus of the solitary tract in rats., Brain Struct Funct, 2015 PubMed
Maniscalco JW, Zheng H, Gordon PJ, Rinaman L., Negative Energy Balance Blocks Neural and Behavioral Responses to Acute Stress by "Silencing" Central Glucagon-Like Peptide 1 Signaling in Rats., J Neurosci, 2015 PubMed
Zheng H, Cai L, Rinaman L., Distribution of glucagon-like peptide 1-immunopositive neurons in human caudal medulla., Brain Struct Funct, 2015 PubMed
Ulrich-Lai YM, Fulton S, Wilson M, Petrovich G, Rinaman L., Stress exposure, food intake and emotional state., Stress, 2015 PubMed

All Publications PubMed

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