Dr. Cathy Levenson
Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 2350B
- Molecular mechanisms of adult neurogenesis: stem cell proliferation, neuronal precursor survival and apoptosis, neuronal differentiation and migration.
- Current Research
- The Levenson Lab investigates the role and regulation of adult stem cells in traumatic brain injury (TBI), with a particular interest in the all too common problem of TBI-associated depression. This work includes examination of the neural stem cell populations found in the adult hippocampus and subventricular zone, and extends to the use of adult human mesenchymal stem cells (hMSC) as a treatment for TBI. Using a well-established pre-clinical model and a full range of genomic, cellular, and behavioral approaches, we are showing that hMSC treatment and nutritional support (e.g., zinc and vitamin A) can prevent TBI-induced depression. We are also developing a comprehensive mechanistic model of how these interventions work at the level of gene expression and stem cell proliferation, survival, and neuronal differentiation.
- Recent Publications
Darkazalli A, Vied C, Badger CD, Levenson CW, Human mesenchymal stem cell treatment normalizes cortical gene expression after traumatic brain injury, J Neurotrauma, 2017 PubMed Morris DR, Levenson CW, Neurotoxicity of Zinc, Adv Neurobiol, 2017 PubMed Cope EC, Morris DR, Gower-Winter SD, Brownstein NC, Levenson CW, Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury, Exp Neurol, 2016 PubMed Darkazalli A, Ismail AA, Abad N, Grant SC, Levenson CW, Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury, Restor Neurol Neurosci, 2016 PubMed Darkazalli A, Ismali AA, Abad N, Grant SC, Levenson CW, Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury, Restor Neurol Neurosci, 2016 PubMed Seth R, Corniola RS, Gower-Winter SD, Morgan TJ Jr, Bishop B, Levenson CW, Zinc deficiency induces apoptosis via mitochondrial p53- and caspase-dependent pathways in human neuronal precursor cells, J Trace Elem Med Biol, 2015 PubMed Muroski ME, Morgan TJ Jr, Levenson CW, Strouse GF, A gold nanoparticle pentapeptide: gene fusion to induce therapeutic gene expression in mesenchymal stem cells, J Am Chem Soc, 2014 PubMed Morris DR, Levenson CW, Zinc in traumatic brain injury: from neuroprotection to neurotoxicity, Curr Opin Clin Nutr Metab Care, 2013 PubMed Morris DR, Levenson CW, Zinc regulation of transcriptional activity during retinoic acid-induced neuronal differentiation, J Nutr Biochem, 2013 PubMed Gower-Winter SD, Corniola RS, Morgan TJ Jr, Levenson CW, Zinc deficiency regulates hippocampal gene expression and impairs neuronal differentiation, Nutr Neurosci, 2013 PubMed Simmons JT, Allen JR, Morris DR, Clark RJ, Levenson CW, Davidson MW, Zhu L, Integrated and passive 1,2,3-triazolyl groups in fluorescent indicators for zinc(II) ions: thermodynamic and kinetic evaluations, Inorg Chem, 2013 PubMed Darkazalli A, Levenson CW, Tracking stem cell migration and survival in brain injury: Current approaches and future prospects, Histol Histopathol, 2012 PubMed Rich NJ, Van Landingham JW, Figueiroa S, Seth R, Corniola RS, Levenson CW, Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury, J Neurosci Res, 2010 PubMed Levenson CW, Somers RC, Nutritionally regulated biomarkers for breast cancer, Nutr Rev, 2008 PubMed Tassabehji NM, Corniola RS, Alshingiti A, Levenson CW, Zinc deficiency induces depression-like symptoms in adult rats, Physiol Behav, 2008 PubMed Corniola RS, Tassabehji NM, Hare J, Sharma G, Levenson CW., Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms, Brain Res, 2008 PubMed Levenson CW, Figueiroa SM, Gestational vitamin D deficiency: long-term effects on the brain, Nutr Rev, 2008 PubMed Levenson CW, Rich NJ, Eat less, live longer? New insights into the role of caloric restriction in the brain, Nutr Rev, 2007 PubMed Hooshmand S, Soung do Y, Lucas EA, Madihally SV, Levenson CW, Arjmandi BH, Genistein reduces the production of proinflammatory molecules in human chondrocytes, J Nutr Biochem, 2007 PubMed Blakemore LJ, Levenson CW, Trombley PQ, Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb, Neuroscience, 2006 PubMed Levenson CW, Zinc: the new antidepressant?, Nutr Rev, 2006 PubMed Levenson CW, Regulation of the NMDA receptor: implications for neuropsychological development, Nutr Rev, 2006 PubMed Levenson CW, Axelrad DM, Too much of a good thing? Update on fish consumption and mercury exposure, Nutr Rev, 2006 PubMed Levenson CW, Zinc supplementation: neuroprotective or neurotoxic?, Nutr Rev, 2005 PubMed Levenson CW, Trace metal regulation of neuronal apoptosis: from genes to behavior, Physiol Behav, 2005 PubMed Tassabehji NM, VanLandingham JW, Levenson CW, Copper alters the conformation and transcriptional activity of the tumor suppressor protein p53 in human Hep G2 cells, Exp Biol Med (Maywood), 2005 PubMed Vanlandingham JW, Tassabehji NM, Somers RC, Levenson CW, Expression profiling of p53-target genes in copper-mediated neuronal apoptosis, Neuromolecular Med, 2005 PubMed Levenson CW, Cutler RG, Ladenheim B, Cadet JL, Hare J, Mattson MP, Role of dietary iron restriction in a mouse model of Parkinson's disease, Exp Neurol, 2004 PubMed Levenson CW, Tassabehji NM, Iron and ageing: an introduction to iron regulatory mechanisms, Ageing Res Rev, 2004 PubMed Evans SA, Overton JM, Alshingiti A, Levenson CW, Regulation of metabolic rate and substrate utilization by zinc deficiency, Metabolism, 2004 PubMed