Florida State University
Kumar 00c9474bb7ebd9c3369aa96e341b16aad2f82374690b3cc2ef871b128d9fd85b

Dr. Sanjay Kumar

Associate Professor of Biomedical Sciences & Neuroscience

Faculty
Biomedical Sciences
MSR 3300B
645-8336

kumar@neuro.fsu.edu

Interest
Neuronal Plasticity, Receptor Biophysics, Temporal Lobe Epilepsy.
Current Research
Basic research in the Kumar laboratory is focused on synaptic physiology underlying neocortical function and plasticity. We are particularly interested in understanding the workings and role of glutamatergic AMPA and N-methyl-D-aspartate Receptors in these processes. Translational research efforts of the lab are focused on deciphering basic pathophysiological mechanisms underlying Temporal Lobe Epilepsy, the most common type of epilepsy in adults. Here, we seek to identify / isolate ictogenic cells and circuits within the parahippocampal region for the purposes of developing therapeutic / interventional strategies to combat TLE. We use a variety of tools and techniques with electrophysiology being the mainstay of our research.
Recent Publications
Abbasi S, Kumar SS., Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy, J Neurophysiol, 2015 PubMed
Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB, N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells, PLoS One, 2015 PubMed
Abbasi S, Kumar SS, Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy, J Neurophysiol, 2014 PubMed
Pilli J, Kumar SS, Potentiation of convergent synaptic inputs onto pyramidal neurons in somatosensory cortex: dependence on brain wave frequencies and NMDA receptor subunit composition, Neuroscience, 2014 PubMed
O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J, Genetic deletion of melatonin receptors enhances murine cognitive and motor performance, Neuroscience, 2014 PubMed
Abbasi S, Kumar SS, Electrophysiological and morphological characterization of cells in superficial layers of rat presubiculum, J Comp Neurol, 2013 PubMed
Pilli J, Kumar SS, Triheteromeric N-methyl-d-aspartate receptors differentiate synaptic inputs onto pyramidal neurons in somatosensory cortex: Involvement of the GluN3A subunit, Neuroscience, 2012 PubMed
Pilli J, Abbasi S, Richardson M, Kumar SS, Diversity and excitability of deep Layer entorhinal cortical neurons in a model of temporal lobe epilepsy, J Neurophysiol, 2012 PubMed
Kumar SS, Jin X, Buckmaster PS, Huguenard JR, Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy, J Neurosci, 2007 PubMed
Kumar SS, Buckmaster PS, Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulata, Brain Res, 2007 PubMed
Kumar SS, Buckmaster PS, Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy, J Neurosci, 2006 PubMed
Kumar SS, Wen X, Yang Y, Buckmaster PS, GABAA receptor-mediated IPSCs and alpha1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy, J Neurophysiol, 2006 PubMed
Kumar SS, Huguenard JR, Pathway specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex, J Neurosci, 2003 PubMed
Kumar SS, Bacci A, Kharazia VK, Huguenard JR, A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons, J Neurosci, 2002 PubMed
Kumar SS, Huguenard, JR, Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex, J Neurophysiol, 2001 PubMed
Kumar SS, Faber DS, Plasticity of first-order sensory synapses: Interactions between homosynaptic LTP and hetrosynaptically evoked dopaminergic potentiation, J Neurosci, 1998 PubMed
Silva A, Kumar SS, Pereda A, Faber DS, Regulation of synaptic strength at mixed synapses: Effects of dopamine receptor blockade and protein kinase C activation, Neuropharmacology, 1995 PubMed

All Publications PubMed

Lab Website

Lab Members

Thomas Sullenberger, Graduate Student

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