Dr. Sanjay Kumar
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 3300B
- Neuronal Plasticity, Receptor Biophysics, Temporal Lobe Epilepsy.
- Current Research
- Basic research in the Kumar laboratory is focused on synaptic physiology underlying neocortical function and plasticity. We are particularly interested in understanding the workings and role of glutamatergic AMPA and N-methyl-D-aspartate Receptors in these processes. Translational research efforts of the lab are focused on deciphering basic pathophysiological mechanisms underlying Temporal Lobe Epilepsy, the most common type of epilepsy in adults. Here, we seek to identify / isolate ictogenic cells and circuits within the parahippocampal region for the purposes of developing therapeutic / interventional strategies to combat TLE. We use a variety of tools and techniques with electrophysiology being the mainstay of our research.
- Recent Publications
Abbasi S, Kumar SS., Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy, J Neurophysiol, 2015 PubMed Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB, N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells, PLoS One, 2015 PubMed Abbasi S, Kumar SS, Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy, J Neurophysiol, 2014 PubMed Pilli J, Kumar SS, Potentiation of convergent synaptic inputs onto pyramidal neurons in somatosensory cortex: dependence on brain wave frequencies and NMDA receptor subunit composition, Neuroscience, 2014 PubMed O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J, Genetic deletion of melatonin receptors enhances murine cognitive and motor performance, Neuroscience, 2014 PubMed Abbasi S, Kumar SS, Electrophysiological and morphological characterization of cells in superficial layers of rat presubiculum, J Comp Neurol, 2013 PubMed Pilli J, Kumar SS, Triheteromeric N-methyl-d-aspartate receptors differentiate synaptic inputs onto pyramidal neurons in somatosensory cortex: Involvement of the GluN3A subunit, Neuroscience, 2012 PubMed Pilli J, Abbasi S, Richardson M, Kumar SS, Diversity and excitability of deep Layer entorhinal cortical neurons in a model of temporal lobe epilepsy, J Neurophysiol, 2012 PubMed Kumar SS, Jin X, Buckmaster PS, Huguenard JR, Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy, J Neurosci, 2007 PubMed Kumar SS, Buckmaster PS, Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulata, Brain Res, 2007 PubMed Kumar SS, Buckmaster PS, Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy, J Neurosci, 2006 PubMed Kumar SS, Wen X, Yang Y, Buckmaster PS, GABAA receptor-mediated IPSCs and alpha1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy, J Neurophysiol, 2006 PubMed Kumar SS, Huguenard JR, Pathway specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex, J Neurosci, 2003 PubMed Kumar SS, Bacci A, Kharazia VK, Huguenard JR, A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons, J Neurosci, 2002 PubMed Kumar SS, Huguenard, JR, Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex, J Neurophysiol, 2001 PubMed Kumar SS, Faber DS, Plasticity of first-order sensory synapses: Interactions between homosynaptic LTP and hetrosynaptically evoked dopaminergic potentiation, J Neurosci, 1998 PubMed Silva A, Kumar SS, Pereda A, Faber DS, Regulation of synaptic strength at mixed synapses: Effects of dopamine receptor blockade and protein kinase C activation, Neuropharmacology, 1995 PubMed