Assistant Professor of Biological Science & Neuroscience
- Biological Science
- KIN 3061
- Epigenetic regulation of neuropsychiatric disorders.
- Current Research
- Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
- Recent Publications
Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ, Role of Tet1 and 5-hydroxymethylcytosine in cocaine action, Nat Neurosci, 2015 PubMed Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ, Beta-catenin mediates stress resilience through Dicer1/microRNA regulation, Nature, 2014 PubMed Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L., Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens, Genome Biology, 2014 PubMed Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ, Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation, Nat Neurosci, 2013 PubMed Feng J, Nestler EJ., Epigenetic mechanisms of drug addiction, Curr Opin Neurobiol, 2013 PubMed Vialou V, Feng J, Robison AJ, Nestler EJ., Epigenetic mechanisms of depression and antidepressant action, Annu Rev Pharmacol Toxicol, 2013 PubMed Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ, Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens, Proc Natl Acad Sci U S A, 2011 PubMed Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G, Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons, Nat Neurosci, 2010 PubMed