Jian Feng

Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g., histone modifications and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.