Florida State University
Jfeng e3fe85b86075c8ecc58b16f97230136874a9d9c340716e96746954bcf01ae9bb

Jian Feng

Assistant Professor of Biological Science & Neuroscience

Faculty
Biological Science
KIN 3061
644-3706

feng@bio.fsu.edu

Interest
Epigenetic regulation of neuropsychiatric disorders.
Current Research
Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
Recent Publications
Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ, Role of Tet1 and 5-hydroxymethylcytosine in cocaine action, Nat Neurosci, 2015 PubMed
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ, Beta-catenin mediates stress resilience through Dicer1/microRNA regulation, Nature, 2014 PubMed
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L., Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens, Genome Biology, 2014 PubMed
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ, Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation, Nat Neurosci, 2013 PubMed
Feng J, Nestler EJ., Epigenetic mechanisms of drug addiction, Curr Opin Neurobiol, 2013 PubMed
Vialou V, Feng J, Robison AJ, Nestler EJ., Epigenetic mechanisms of depression and antidepressant action, Annu Rev Pharmacol Toxicol, 2013 PubMed
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ, Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens, Proc Natl Acad Sci U S A, 2011 PubMed
Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G, Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons, Nat Neurosci, 2010 PubMed

All Publications PubMed

Lab Website

Lab Members

Jacob Brewer, Graduate Student

Amber Brown, Lab Manager

Javed Chitaman, Graduate Student

Rachel Hedinger, Graduate Student

Graham Kaplan, Graduate Student

Haiyang Xu, Postdoctoral Associate

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