Dr. James Fadool is currently accepting new students.
Dr. James Fadool
Associate Professor of Biological Science & Neuroscience
- Biological Science
- KIN 3018
- Retinal Development, Photoreceptor Degeneration, Regeneration, Synaptic Plasticity, Zebrafish Genetics
- Current Research
- Have you ever wondered what controls the development of the nervous system? What genes regulated the number and types of neurons generated during development? What guides formation of the synapse? How the brain responds to injury? What allows some species retain the capacity for neural regeneration and regain function but limits our own capacity for repair? The zebrafish visual system offers many advantages as a model system to answer these questions. Retinal anatomy, physiology and development are highly conserved in virtually all vertebrates. The zebrafish retina is cone-dominated like our fovea, and the cones are arranged in a highly ordered mosaic. In our work, we combine a variety of approaches spanning embryological manipulations and behavior, to forward genetic screens, genome-editing, transgenesis, and live confocal imaging.
- Recent Publications
Sotolongo-Lopez M, Alvarez-Delfin K, Saade CJ, Vera DL, Fadool JM, Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish, PLoS Genet, 2016 PubMed Taylor SM, Alvarez-Delfin K, Saade CJ, Thomas JL, Thummel R, Fadool JM, Hitchcock PF, The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling, Invest Ophthalmol Vis Sci, 2015 PubMed Yoshimatsu T, Williams PR, D'Orazi FD, Suzuki SC, Fadool JM, Allison WT, Raymond PA, Wong RO, Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells, Nat Commun, 2014 PubMed Saade CJ, Alvarez-Delfin K, Fadool JM, Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish, J Neurosci, 2013 PubMed Morris AC, Forbes-Osborne MA, Pillai LS, Fadool JM, Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration, Invest Ophthalmol Vis Sci, 2011 PubMed Alvarez-Delfin K, Morris AC, Snelson CD, Gamse JT, Gupta T, Marlow FL, Mullins MC, Burgess HA, Granato M, Fadool JM, Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development, Proc Natl Acad Sci U S A, 2009 PubMed Morris AC, Scholz TL, Brockerhoff SE, Fadool JM, Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina, Dev Neurobiol, 2008 PubMed Fadool JM, Dowling JE, Zebrafish: A Model System for the Study of Eye Genetics, Prog Retin Eye Res, 2008 PubMed Stearns G, Evangelista M, Fadool JM, Brockerhoff SE, A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish, J Neurosci, 2007 PubMed Fuller RC, Carleton KL, Fadool JM, Spady TC, Travis J, Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei, J Evol Biol, 2005 PubMed Vihtelic TS, Fadool JM, Thornton K, Hyde DR, Wistow G, Expressed sequence tag analysis of zebrafish eye tissues for NEIBank, Mol Vis, 2005 PubMed Morris AC, Schroeter EH, Bilotta J, Wong RO, Fadool JM, Cone survival despite rod degeneration in transgenic zebrafish, Invest Ophthalmol Vis Sci, 2005 PubMed DeCarvalho AC, Cappendijk S, Fadool JM, Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish, Dev Dyn, 2004 PubMed Fadool JM, Development of a rod photoreceptor mosaic revealed in transgenic zebrafish, Dev Biol, 2003 PubMed McCune AR, Fuller RC, Aquilina AA, Dawley RM, Fadool JM, Houle D, Travis J, Kondrashov AS, A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish, Science, 2002 PubMed Fadool JM, Hartl DL, Dowling JE, Transposition of the mariner element from Drosophila mauritiana in zebrafish, Proc Natl Acad Sci U S A, 1998 PubMed Fadool JM, Brockerhoff SE, Hyatt GA, Dowling JE, Mutations affecting eye morphology in the developing zebrafish (Danio rerio), Dev Genet, 1997 PubMed