Dr. Gregg Stanwood
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- We study how genes and environment contribute to the formation and function of brain circuits that mediate cognitive, motivational and emotional responses. Dysregulation of these processes during critical periods of maturation contributes to development of mental health and neurological disorders.
- Current Research
- We primarily work in mouse models of human disease and use pharmacological, behavioral, cell biological, and neuroanatomical methods. In one series of studies we are assessing the roles for dopamine D1 and D2 receptors in the differentiation of forebrain interneurons, and studying how loss and gain of function in the dopamine system leads to neuropsychiatric disorders later in life. In another project, we are focusing on an important insulin regulator in the brain, GLP-1, and how GLP-1 receptors can regulate drug reward, dopamine homeostasis, and responses to stress.
- Recent Publications
Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD, Blakely RD, Bonnin A, Veenstra-VanderWeele J, Impact of maternal serotonin transporter genotype on placental serotonin, fetal forebrain serotonin, and neurodevelopment, Neuropsychopharmacology, 2017 PubMed Martin MM, Graham DL, McCarthy DM, Bhide PG, Stanwood GD, cocaine-induced neurodevelopmental deficits and underlying mechanisms, Birth Defects Res C Embryo Today, 2016 PubMed Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A., Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. , Transl Psychiatry, 2016 PubMed Sørensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A, Fink-Jensen A, The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice., Physiol Behav., 2015 PubMed Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA, Evidence against dopamine D1/D2 receptor heteromers, Mol Psychiatry, 2015 PubMed Graham DL, Durai HH, Garden JD, Cohen EL, Echevarria FD, Stanwood GD, Loss of dopamine D2 receptors increases parvalbumin-positive interneurons in the anterior cingulate cortex, ACS Chem Neurosci, 2015 PubMed Ross EJ, Graham DL, Money KM, Stanwood GD, Developmental consequences of fetal exposure to drugs: what we know and what we still must learn, Neuropsychopharmacology, 2015 PubMed Sørensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A, Fink-Jensen A, The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice, Physiol Behav, 2015 PubMed Graham DL, Buendia MA, Chapman MA, Durai HH, Stanwood GD, Deletion of Galphaq in the telencephalon alters specific neurobehavioral outcomes, Synaps, 2015 PubMed Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD, The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants, Proc Natl Acad Sci U S A, 2014 PubMed Money KM, Stanwood GD, Developmental origins of brain disorders: roles for dopamine, Front Cell Neurosci, 2013 PubMed Graham DL, Erreger K, Galli A, Stanwood GD, GLP-1 analog attenuates cocaine reward, Mol Psychiatry, 2013 PubMed Killinger CE, Robinson S, Stanwood GD, Subtle biobehavioral effects produced by paternal cocaine exposure, Synapse, 2012 PubMed Frederick AL, Saborido TP, Stanwood GD, Neurobehavioral phenotyping of G(alphaq) knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair, Front Behav Neurosci, 2012 PubMed Thompson BL, Levitt P, Stanwood GD, Prenatal exposure to drugs: effects on brain development and implications for policy and education, Nat Rev Neurosci, 2009 PubMed Stanwood GD, Levitt P, Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution, J Neurosci., 2007 PubMed , , ,