Dr. Debra Ann Fadool is currently accepting new graduate students.
Dr. Debra Ann Fadool
Nancy Marcus Professor of Biological Science, Director of Chemical Senses Training Grant Program
- Biological Science
- KIN 3008
- Olfactory Signal Transduction and Neuromodulation of Ion Channels.
- Current Research
- We have discovered that hormones and neurotrophins [glucagon-like peptide 1 (glp-1), insulin, and brain-derived neurotrophic factor (BDNF)] modulate electrical activity in the brain at the level of the ion channel via phosphorylation. These types of signaling molecules are also involved in maintaining energy homeostasis. Currently, we hypothesize that the olfactory system not only senses our external chemical environment (odors) but is a detector of internal chemistry, the chemistry of metabolism. As such, we are studying the neuropathology of diabetes and obesity - how sensory systems, such as the olfactory system are perturbed by diet-induced obesity at the level of the ion channel using electrophysiology, nanotechnology, and optogenetics. I serve also as the director of our NIH Chemical Senses Training Grant, for which predoctoral students and postdoctoral scholars can read about special training opportunities (see link above right).
- Recent Publications
Schwartz AB, Kapur A, Wang W, Huang Z, Fardone E, Palui G, Mattoussi H, Fadool DA, Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3, J Neurochem, 2017 PubMed Julliard AK, Al Koborssy D, Fadool DA, Palouzier-Paulignan B, Nutrient sensing: Another chemosensitivity of the olfactory system, Front Physiol, 2017 PubMed Huang Z, Thiebaud N, Fadool DA, Differential serotonergic modulation across the main and accessory olfactory bulbs, J Physiol, 2017 PubMed Bell GA, Fadool DA, Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice, Physiol Behav, 2017 PubMed Velez P, Schwartz AB, Iyer SR, Warrington A, Fadool DA, Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting, J Neurophysiol, 2016 PubMed Kovach CP, Al Koborssy D, Huang Z, Chelette BM, Fadool JM, Fadool DA, Mitochondrial ultrastructure and glucose signaling pathways attributed to the Kv1.3 ion channel, Front Physiol, 2016 PubMed McCarthy DM, Bell GA, Cannon EN, Mueller KA, Huizenga MN, Sadri-Vakili G, Fadool DA, Bhide PG, Reversal learning deficits associated with increased frontal cortical brain-derived neurotrophic factor tyrosine kinase B signaling in a prenatal cocaine exposure mouse model, Dev Neurosci, 2016 PubMed Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA, The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel, J Physiol, 2016 PubMed Spear JM, Koborssy DA, Schwartz AB, Johnson AJ, Audhya A, Fadool DA, Stagg SM, Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a, BMC Biochem, 2015 PubMed Thiebaud N, Johnson MC, Butler JL, Bell GA, Ferguson KL, Fadool AR, Fadool JC, Gale AM, Gale DS, Fadool DA, Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning, J Neurosci, 2014 PubMed Johnson MC, Biju KC, Hoffman J, Fadool DA, Odor enrichment sculpts the abundance of olfactory bulb mitral cells, Neurosci Lett, 2013 PubMed Tucker K, Cho S, Thiebaud N, Henderson M, Fadool DA, Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel, J Physiol, 2013 PubMed Tucker K, Michael Overton J, Fadool DA, Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent, J Neuroendocrinol, 2012 PubMed Mast TG, Fadool DA, Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb, PLoS One, 2012 PubMed Palouzier-Paulignan B, Lacroix MC, Aimé P, Baly C, Caillol M, Congar P, Julliard AK, Tucker K, Fadool DA, Olfaction Under Metabolic Influences, Chem Senses, 2012 PubMed Corthell JT, Fadool DA, Trombley PQ, Connexin and AMPA receptor expression changes over time in the rat olfactory bulb, Neuroscience, 2012 PubMed Tucker KR, Godbey SJ, Thiebaud N, Fadool DA, Olfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity, Physiol Behav, 2012 PubMed Fadool DA, Tucker K, Pedarzani P, Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel, PLoS One, 2011 PubMed Mast TG, Brann JH, Fadool DA, The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ, BMC Neurosci, 2010 PubMed Tucker K, Cavallin MA, Jean-Baptiste P, Biju KC, Overton JM, Pedarzani P, Fadool DA, The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel, Results Probl Cell Differ, 2010 PubMed Marks DR, Tucker K, Cavallin MA, Mast TG, Fadool DA, Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors, J Neurosci, 2009 PubMed Colley BS, Cavallin MA, Biju K, Marks DR, Fadool DA, Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc, BMC Neurosci, 2009 PubMed Tucker K, Overton JM, Fadool DA, Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice, Int J Obes, 2008 PubMed Biju KC, Marks DR, Mast TG, Fadool DA, Deletion of voltage-gated channel affects glomerular refinement and odor receptor expression in the olfactory system, J Comp Neurol, 2008 PubMed