Florida State University
Dafadool b866289969d29ac1ae0b736f98555e6981768507f4100898f11025a8318b49b6

Dr. Debra Ann Fadool

Nancy Marcus Professor of Biological Science, Director of Chemical Senses Training Grant Program

Faculty
Biological Science
KIN 3008
644-4775

dafadool@neuro.fsu.edu

Interest
Olfactory Signal Transduction and Neuromodulation of Ion Channels.
Current Research
We have discovered that hormones and neurotrophins [glucagon-like peptide 1 (glp-1), insulin, and brain-derived neurotrophic factor (BDNF)] modulate electrical activity in the brain at the level of the ion channel via phosphorylation. These types of signaling molecules are also involved in maintaining energy homeostasis. Currently, we hypothesize that the olfactory system not only senses our external chemical environment (odors) but is a detector of internal chemistry, the chemistry of metabolism. As such, we are studying the neuropathology of diabetes and obesity - how sensory systems, such as the olfactory system are perturbed by diet-induced obesity at the level of the ion channel using electrophysiology, nanotechnology, and optogenetics. I serve also as the director of our NIH Chemical Senses Training Grant, for which predoctoral students and postdoctoral scholars can read about special training opportunities (see link above right).
Recent Publications
Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA, The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel, J Physiol, 2016 PubMed
Spear JM, Koborssy DA, Schwartz AB, Johnson AJ, Audhya A, Fadool DA, Stagg SM, Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a, BMC Biochem, 2015 PubMed
Thiebaud N, Johnson MC, Butler JL, Bell GA, Ferguson KL, Fadool AR, Fadool JC, Gale AM, Gale DS, Fadool DA, Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning, J Neurosci, 2014 PubMed
Johnson MC, Biju KC, Hoffman J, Fadool DA, Odor enrichment sculpts the abundance of olfactory bulb mitral cells, Neurosci Lett, 2013 PubMed
Tucker K, Cho S, Thiebaud N, Henderson M, Fadool DA, Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel, J Physiol, 2013 PubMed
Tucker K, Michael Overton J, Fadool DA, Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent, J Neuroendocrinol, 2012 PubMed
Mast TG, Fadool DA, Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb, PLoS One, 2012 PubMed
Palouzier-Paulignan B, Lacroix MC, Aimé P, Baly C, Caillol M, Congar P, Julliard AK, Tucker K, Fadool DA, Olfaction Under Metabolic Influences, Chem Senses, 2012 PubMed
Corthell JT, Fadool DA, Trombley PQ, Connexin and AMPA receptor expression changes over time in the rat olfactory bulb, Neuroscience, 2012 PubMed
Tucker KR, Godbey SJ, Thiebaud N, Fadool DA, Olfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity, Physiol Behav, 2012 PubMed
Fadool DA, Tucker K, Pedarzani P, Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel, PLoS One, 2011 PubMed
Mast TG, Brann JH, Fadool DA, The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ, BMC Neurosci, 2010 PubMed
Tucker K, Cavallin MA, Jean-Baptiste P, Biju KC, Overton JM, Pedarzani P, Fadool DA, The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel, Results Probl Cell Differ, 2010 PubMed
Marks DR, Tucker K, Cavallin MA, Mast TG, Fadool DA, Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors, J Neurosci, 2009 PubMed
Colley BS, Cavallin MA, Biju K, Marks DR, Fadool DA, Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc, BMC Neurosci, 2009 PubMed
Tucker K, Overton JM, Fadool DA, Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice, Int J Obes, 2008 PubMed
Biju KC, Marks DR, Mast TG, Fadool DA, Deletion of voltage-gated channel affects glomerular refinement and odor receptor expression in the olfactory system, J Comp Neurol, 2008 PubMed

All Publications PubMed

Lab Website

Training Grant Opportunities

Lab Members

Dolly Al Koborssy, Graduate Student

Genevieve Bell, Graduate Student

Brandon Chelette, Graduate Student

Louis Collings, Graduate Student - Molecular Biophysics

Erminia Fardone, Postdoctoral Associate

Kassandra Ferguson, Graduate Student

Zhenbo Huang, Graduate Student

Austin Schwartz, Graduate Student - Molecular Biophysics

Nicolas Thiebaud, Affiliate

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