Dr. Choogon Lee
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 2300L
- Circadian biology and metabolism.
- Current Research
- Our circadian clock is our body’s way of telling time, and it drives daily oscillations across our physiology and behavior: not only when we sleep and wake, but also our metabolism, digestive function, cardiac function, cognitive and emotional state, and tissue repair. We use mutant and transgenic mouse models along with mathematical models to emulate human sleep and circadian disorders. Our second line of research in the lab is driven by the fact that serious metabolic diseases such as obesity and type 2 diabetes continue to become more and more prevalent in Western nations due to changes in our dietary habits and lifestyle. While others are trying to tackle this problem through social, psychological, and neurobiological (e.g., modulation of appetite) approaches, we are exploring the possibility of treating these diseases through modulation of cell-intrinsic metabolic pathways such as glycolysis.
- Recent Publications
Yoo SH, Kojima S, Shimomura K, Koike N, Buhr ED, Furukawa T, Ko CH, Gloston G, Ayoub C, Nohara K, Reyes BA, Tsuchiya Y, Yoo OJ, Yagita K, Lee C, Chen Z, Yamazaki S, Green CB, Takahashi JS, Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation, Proc Natl Acad Sci U S A, 2017 PubMed Kettner MN, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L, Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis, Cancer Cell, 2016 PubMed Matsu-Ura T, Dovzhenok A, Aihara E, Rood J, Le H, Ren Y, Rosselot AE, Zhang T, Lee C, Obrietan K, Montrose MH, Lim S, Moore SR, Hong CI, Intercellular coupling of the cell cycle and circadian clock in adult stem cell culture, Mol Cell, 2016 PubMed Pramudya I, Rico CG, Lee C, Chung H, POSS-Containing bioinspired adhesives with enhanced mechanical and optical properties for biomedical applications, Biomacromolecules, 2016 PubMed Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L, Circadian Dysfunction Induces Leptin Resistance in Mice, Cell Metab, 2015 PubMed Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N, Light-regulated translational control of circadian behavior by eIF4E phosphorylation, Nat Neurosci, 2015 PubMed D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C, A tunable artificial circadian clock in clock-defective mice, Net Commun, 2015 PubMed Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG, Casein kinase 1?-dependent Wee1 protein degradation, J Biol Chem, 2014 PubMed Chen R, D'Alessandro M, Lee C, miRNAs are required for generating a time delay critical for the circadian oscillator, Curr Biol, 2013 PubMed Bhatwadekar AD, Yan Y, Qi X, Thinschmidt JS, Neu MB, Li Calzi S, Shaw LC, Dominiguez JM, Busik JV, Lee C, Boulton ME, Grant MB, Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow, Diabetes, 2013 PubMed Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, Takahashi JS, Transcriptional architecture and chromatin landscape of the core circadian clock in mammals, Science, 2012 PubMed Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C, The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1, Proc Natl Acad Sci U S A, 2011 PubMed Lee Y, Chen R, Lee HM, Lee C, Stoichiometric relationship among clock proteins determines robustness of circadian rhythms, J Biol Chem, 2011 PubMed Lee C, Chen R, Lee HM, PERpetual motion of the circadian negative feedback loop, Cell Cycle, 2010 PubMed Ansari N, Agathagelidis M, Lee C, Korf H, von Gall C, Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny, Eur J Neurosci, 2009 PubMed Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong H, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J, Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis, Science, 2009 PubMed Chen R, Schirmer A, Lee Y, Lee H, Kumar V, Yoo SH, Takahashi JS, Lee C, Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism, Mol Cell, 2009 PubMed Lee H, Chen R, Lee Y, Yoo S, Lee C, Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock, Proc Natl Acad Sci U S A, 2009 PubMed Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA, Lee C, Nikitin AY, Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis, Cell Cycle, 2008 PubMed Chen R, Seo D, Bell E, von Gall C, Lee C, Strong resetting of the mammalian clock by constant light followed by constant darkness, J Neurosci, 2008 PubMed Siepka SM, Yoo S, Park J, Lee C, Takahashi JS, Genetics and Neurobiology of Circadian Clocks in Mammals, Cold Spring Harb Symp Quant Biol, 2007 PubMed Siepka SM, Yoo S, Park J, Song W, Kumar V, Hu Y, Lee C, Takahashi JS, Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression, Cell, 2007 PubMed Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho S, Draetta GF, Pagano M, SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins, Science, 2007 PubMed Kondratov RV, Kondratova AA, Lee C, Gorbacheva VY, Chernov MV, Antoch MP, Post-Translational Regulation of Circadian Transcriptional CLOCK(NPAS2)/BMAL1 Complex by CRYPTOCHROMES, Cell Cycle, 2006 PubMed Yoo SH, Ko C, Lowrey P, Buhr E, Song EJ, Chang S, Yoo OJ, Yamazaki S, Lee C, Takahashi JS, A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo, Proc Natl Acad Sci U S A, 2005 PubMed Lee C, Weaver DR, Reppert SM, Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock, Mol Cell Biol, 2004 PubMed D'Alessandro M, Beesley S, Kim JK, Jones Z, Chen R, Wi J, Kyle K, Vera D, Pagano M, Nowakowski R, Lee C, Stability of wake-sleep cycles requires robust degradation of the PERIOD protein, Current Biology,