Dr. Richard Bertram
Brennan Professor of Mathematics, Neuroscience, and Molecular Biophysics
- LOV 109 and IMB 402
- The mechanisms underlying pulsatile hormone secretion and patterned neural activity.
- Current Research
- Hormones are often secreted from endocrine cells in a pulsatile manner, and downstream targets respond optimally to pulsatile input, demonstrating a physiological significance of this pattern of secretion. One focus of the research done in my lab is the biophysical mechanisms underlying this pulsatility. Much of our work is on insulin-secreting beta cells that are located in pancreatic islets of Langerhans, and on cells of the pituitary gland that secrete hormones related to reproduction and stress. The other major focus of my lab is on mechanisms through which networks of neurons produce patterned behavior. In particular, we are examining the neural basis of birdsong production in the zebra finch, which serves as an excellent model system for learned patterned behavior. The techniques used in my lab are largely mathematical or computational, typically done in close collaboration with experimental labs.
- Recent Publications
Bertram R, Rubin JE, Multi-timescale systems and fast-slow analysis, Mathematical Biosciences, 2017 PubMed Elliot KC, Wu W, Bertram R, Hyson RL, Johnson F, Orthogonal topography in the parallel input architecture of songbird HVC, J Comp Neurol., 2017 PubMed Galvis D, Wu W, Hyson RL, Johnson F, Bertram R, A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production, J Neurophysiol, 2017 PubMed Weingard D, Blanco W, Steinbock O, Bertram R, Stabilization of collapsing scroll waves in systems with random heterogeneities, Chaos, 2017 PubMed Yildirim V, Bertram R, Calcium oscillation frequency-sensitive gene regulation and homeostatic compensation in pancreatic B-cells, Bull Math Biol., 2017 PubMed Yildirim V, Vadrevu S, Thompson B, Satin LS, Bertram R, Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets, PLoS Comput Biol., 2017 PubMed Stathopoulos AM, Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Bertram R, Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats., Endocrine, 2016 PubMed Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ., Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs., Endocrinology, 2016 PubMed McKenna JP, Dhumpa R, Mukhitov N, Roper MG, Bertram R, Glucose oscillations can activate an endogenous oscillator in pancreatic islets, PLoS Computational Biology, 2016 PubMed Yi L, Bandak B, Wang X, Bertram R, Roper MG, Dual detection system for simultaneous measurement of intracellular fluorescent markers and cellular secretion, Analytical Chemistry, 2016 PubMed Tagliavini A, Tabak J, Bertram R, Pedersen MG, Is bursting more effective than spiking in evoking pituitary hormone secretion? A spatiotemporal simulation study of calcium and granule dynamics, Am J Physiol Endocrinol Metab, 2016 PubMed Stathopoulos AM, Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Bertram R, Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats, Endocrine, 2016 PubMed Fletcher P, Bertram R, Tabak J, From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability, J Comput Neurosci, 2016 PubMed McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R, Ca(2+) Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity, Biophys J, 2016 PubMed Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS, Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet beta-Cells, Biophys J, 2016 PubMed Gonzalez-Iglesias AE, Fletcher PA, Arias-Cristancho JA, Cristancho-Gordo R, Helena CV, Bertram R, Tabak J, Direct stimulatory effects of oxytocin in female rat gonadotrophs and somatotrophs in vitro: comparison with lactotrophs, Endocrinology, 2015 PubMed Peercy BE, Sherman AS, Bertram R, Modeling of glucose-induced cAMP oscillations in pancreatic beta cells: cAMP rocks when metabolism rolls, Biophys J, 2015 PubMed Bertram R, Mathematical modeling in neuroendocrinology, Compr Physiol, 2015 PubMed Helena CV, Toporikova N, Kalil B, Stathopoulos AM, Pogrebna VV, Carolino RO, Anselmo-Franci JA, Bertram R, KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats, Endocrinology, 2015 PubMed Elliott KC, Wu W, Bertram R, Johnson F, Disconnection of a basal ganglia circuit in juvenile songbirds attenuates the spectral differentiation of song syllables, Dev Neurobiol, 2014 PubMed Bertram R, Daou A, Hyson RL, Johnson F, Wu W, Two neural streams, one voice: Pathways for theme and variation in the songbird brain, Neuroscience, 2014 PubMed Duncan PJ, Sengul S, Tabak J, Ruth P, Bertram R, Shipston MJ, Large conductance Ca2+ -activated K+ channels (BK) promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs, J Physiol, 2014 PubMed Basista MJ, Elliott KC, Wu W, Hyson RL, Bertram R, Johnson F, Independent premotor encoding of the sequence and structure of birdsong in avian cortex, J Neurosci, 2014 PubMed Sengül S, Clewley R, Bertram R, Tabak J, Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model, J Comput Neurosci, 2014 PubMed Dhumpa R, Truong TM, Wang X, Bertram R, Roper MG, Negative feedback synchronizes islets of Langerhans, Biophys J, 2014 PubMed Szawka RE, Poletini MO, Leite CM, Bernuci MP, Kalil B, Mendonça LB, Carolino RO, Helena CV, Bertram R, Franci CR, Anselmo-Franci JA, Release of norepinephrine in the preoptic area activates anteroventral periventricular nucleus neurons and stimulates the surge of luteinizing hormone, Endocrinology, 2013 PubMed Corthell JT, Stathopoulos AM, Watson CC, Bertram R, Trombley PQ, Olfactory bulb monoamine concentrations vary with time of day, Neuroscience, 2013 PubMed Daou A, Ross MT, Johnson F, Hyson RL, Bertram R, Electrophysiological characterization and computational models of HVC neurons in the zebra finch, J Neurophysiol, 2013 PubMed Chu Z, Tomaiuolo, Bertram R, Moenter SM, Two types of burst firing in gonadotrophin-releasing hormone neurones, J Neuroendocrinol, 2012 PubMed Poletini MO, McKee DT, Szawka RE, Bertram R, Helena CV, Freeman ME, Cervical stimulation activates A1 and locus coeruleus neurons that project to the paraventricular nucleus of hypothalamus, Brain Research Bulletin, 2012 PubMed Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Tabak J, Bertram R, Freeman ME, Systemic oxytocin induces a prolactin secretory rhythm via the pelvic nerve in ovariectomized rats, Am J Physiol Regul Integr Comp Physiol, 2011 PubMed Thompson JA, Basista MJ, Wu W, Bertram R, & Johnson F, Dual Pre-Motor Contribution to Songbird Syllable Variation, J Neurosci, 2011 PubMed Sirzen-Zelenskaya A, Gonzalez-Iglesias AE, de Monvel JB, Bertram R, Freeman ME, Gerber U, Egli M, Prolactin induces a hyperpolarizing current in rat paraventricular oxytocinergic neurons, J Neuroendocrinol, 2011 PubMed Tabak J, Tomaiuolo M, Gonzalez-Iglesias AE, Milescu LS, Bertram R, Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: A dynamic clamp study, J Neurosci, 2011 PubMed Teka W, Tabak J, Vo T, Wechselberger M, Bertram R, The dynamics underlying pseudo-plateau bursting in a pituitary cell model, J Math Neurosci, 2011 PubMed Tabak J, Mascagni M, Bertram R, Mechanism for the universal pattern of activity in developing neuronal networks, J Neurophysiol, 2010 PubMed Bertram R, Helena CV, Gonzalez-Iglesias AE, Tabak J, Freeman ME, A tale of two rhythms: The emerging roles of oxytocin in rhythmic prolactin release, J Neuroendocrinol, 2010 PubMed Tabak J, Gonzalez-Iglesias AE, Toporikova N, Bertram R and Freeman ME, Variations in the response of pituitary lactotrophs to oxytocin during the rat estrous cycle, Endocrinology, 2010 PubMed Tomaiuolo M, Bertram R, Gonzalez-Iglesias AE, Tabak J, Investigating heterogeneity of intracellular calcium dynamics in anterior pituitary lactotrophs using a combined modelling/experimental approach, J Neuroendocrinol, 2010 PubMed Matveev V, Bertram R, Sherman A, Ca2+ current versus Ca2+ channel cooperativity of exocytosis, J Neurosci, 2009 PubMed Fendler B, Zhang M, Satin L, Bertram R, Synchronization of pancreatic islet oscillations by intrapancreatic ganglia: a modeling study, Biophys J, 2009 PubMed Helena CV, McKee DT, Bertram R, Walker AM, Freeman ME, The rhythmic secretion of mating-induced prolactin secretion is controlled by prolactin acting centrally, Endocrinology, 2009 PubMed