Dr. Michelle Arbeitman
Associate Professor of Biomedical Sciences & Neuroscience
- Biomedical Sciences
- MSR 3350M
- The Arbeitman lab studies the molecular-genetic specification of behaviors, with a focus on reproductive behaviors in fruit flies and mice. The goal is to understand how genes specify the potential for behavior in these well-studied model systems that allow for rapid progress as models for human disease analyses. The lab uses genomic, molecular-genetic, biochemical, developmental and computational approaches to address the genetic specification of behavior.
- Current Research
- Understanding how complex behaviors are specified at a molecular-genetic level is a major unsolved question in biology, for which we have very little understanding in any organism. The lab focuses on unlocking the molecular mechanisms used to specify sexual dimorphism in the nervous system that underlies differences in male and female reproductive behaviors using fruit flies and mice as a model.
- Recent Publications
Vied C, Ray S, Badger CD, Bundy JL, Arbeitman MN, Nowakowski RS, Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests basis for sex-specific susceptibility and severity of neurological disorders, J Comp Neurol, 2016 PubMed Arbeitman MN, Newell NR, Courtship Love Songs: doublesex Makes the Connection., Dev Cell, 2016 PubMed Newell NR, New FN, Dalton JE, McIntyre LM, Arbeitman MN., Neurons That Underlie Drosophila melanogaster Reproductive Behaviors: Detection of a Large Male-Bias in Gene Expression in fruitless-Expressing Neurons., G3 (Bethesda), 2016 PubMed Arbeitman MN, New FN, Fear JM, Howard TS, Dalton JE, Graze RM., Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex., G3 (Bethesda), 2016 PubMed Signor SA, Arbeitman MN, Nuzhdin SV., Gene networks and developmental context: the importance of understanding complex gene expression patterns in evolution., Evol Dev, 2016 PubMed Ray S, Tzeng RY, DiCarlo LM, Bundy JL, Vied C, Tyson G, Nowakowski R, Arbeitman MN, An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period, G3 (Bethesda), 2015 PubMed Fear JM, Arbeitman MN, Salomon MP, Dalton JE, Tower J, Nuzhdin SV, McIntyre LM, The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster, BMC Syst Biol, 2015 PubMed Arbeitman MN, Kopp A, L Siegal M, Van Doren M, The genetics of sex: exploring differences, Genetics, 2014 PubMed Dalton JE, Fear JM, Knott S, Baker BS, McIntyre LM, Arbeitman MN, Male-specific Fruitless isoforms have different regulatory roles conferred by distinct zinc finger DNA binding domains, BMC Genomics, 2013 PubMed Winbush A, Reed D, Chang PL, Nuzhdin SV, Lyons LC, Arbeitman MN, Identification of gene expression changes associated with long-term memory of courtship rejection in Drosophila males, G3 (Bethesda), 2012 PubMed Thomas A, Lee PJ, Dalton JE, Nomie KJ, Stoica L, Costa-Mattioli M, Chang P, Nuzhdin S, Arbeitman MN, Dierick HA, A versatile method for cell-specific profiling of translated mRNAs in Drosophila, PLoS One, 2012 PubMed Chang PL, Dunham JP, Nuzhdin SV, Arbeitman MN, Somatic sex-specific transcriptome differences in Drosophila revealed by whole transcriptome sequencing, BMC Genomics, 2011 PubMed Masly JP, Dalton JE, Srivastava S, Chen L, Arbeitman MN, The genetic basis of rapidly evolving male genital morphology in Drosophila, Genetics, 2011 PubMed Dalton JE, Kacheria TS, Knott SR, Lebo MS, Nishitani A, Sanders LE, Stirling EJ, Winbush A, Arbeitman MN, Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster, BMC Genomics, 2010 PubMed Dalton JE, Lebo MS, Sanders LE, Sun F, Arbeitman MN, Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors, Curr Biol, 2009 PubMed
Hongru Hu, Graduate Student